Seroatlas · Human Serome Atlas

ARAP2

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2

Also known as: ARAP2_HUMAN, CENTD1, PARX

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WZ64
Gene: ARAP2
Ensembl: ENSG00000047365
Chromosome: 4
Canonical length: 1704 aa
Protein class: Predicted intracellular proteins
Subcellular location: Actin filaments,Focal adhesion sites

OverviewNCBI Gene

The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]

Canonical amino-acid sequenceUniProt

1704 residues, UniProt reviewed canonical sequence.

>Q8WZ64|ARAP2
     1  MSSVSEVNVD IKDFLMSINL EQYLLHFHES GFTTVKDCAA INDSLLQKIG ISPTGHRRRI
    61  LKQLQIILSK MQDIPIYANV HKTKKNDDPS KDYHVPSSDQ NICIELSNSG SVQTSSPPQL
   121  ETVRKNLEDS DASVERSQYP QSDDKLSPPK RDFPTAEEPH LNLGSLNDSL FGSDNIKIES
   181  LITKKTVDHT VEEQQTEKVK LITENLSKLP NADSECLSFV GCSTSGTNSG NGTNGLLEGS
   241  PPSPFFKFQG EMIVNDLYVP SSPILAPVRS RSKLVSRPSR SFLLRHRPVP EIPGSTKGVS
   301  GSYFRERRNV ATSTEKSVAW QNSNEENSSS IFPYGETFLF QRLENSKKRS IKNEFLTQGE
   361  ALKGEAATAT NSFIIKSSIY DNRKEKISED KVEDIWIPRE DKNNFLIDTA SESEYSTVEE
   421  CFQSLRRKNS KASKSRTQKA LILDSVNRHS YPLSSTSGNA DSSAVSSQAI SPYACFYGAS
   481  AKKVKSGWLD KLSPQGKRMF QKRWVKFDGL SISYYNNEKE MYSKGIIPLS AISTVRVQGD
   541  NKFEVVTTQR TFVFRVEKEE ERNDWISILL NALKSQSLTS QSQAVVTPEK CGYLELRGYK
   601  AKIFTVLSGN SVWLCKNEQD FKSGLGITII PMNVANVKQV DRTVKQSFEI ITPYRSFSFT
   661  AETEKEKQDW IEAVQQSIAE TLSDYEVAEK IWFNESNRSC ADCKAPDPDW ASINLCVVIC
   721  KKCAGQHRSL GPKDSKVRSL KMDASIWSNE LIELFIVIGN KRANDFWAGN LQKDEELHMD
   781  SPVEKRKNFI TQKYKEGKFR KTLLASLTKE ELNKALCAAV VKPDVLETMA LLFSGADVMC
   841  ATGDPVHSTP YLLAKKAGQS LQMEFLYHNK FSDFPQHDIH SEGVLSQESS QSTFLCDFLY
   901  QAPSAASKLS SEKKLLEETN KKWCVLEGGF LSYYENDKST TPNGTININE VICLAIHKED
   961  FYLNTGPIFI FEIYLPSERV FLFGAETSQA QRKWTEAIAK HFVPLFAENL TEADYDLIGQ
  1021  LFYKDCHALD QWRKGWFAMD KSSLHFCLQM QEVQGDRMHL RRLQELTIST MVQNGEKLDV
  1081  LLLVEKGRTL YIHGHTKLDF TVWHTAIEKA AGTDGNALQD QQLSKNDVPI IVNSCIAFVT
  1141  QYGLGCKYIY QKNGDPLHIS ELLESFKKDA RSFKLRAGKH QLEDVTAVLK SFLSDIDDAL
  1201  LTKELYPYWI SALDTQDDKE RIKKYGAFIR SLPGVNRATL AAIIEHLYRV QKCSEINHMN
  1261  AHNLALVFSS CLFQTKGQTS EEVNVIEDLI NNYVEIFEVK EDQVKQMDIE NSFITKWKDT
  1321  QVSQAGDLLI EVYVERKEPD CSIIIRISPV MEAEELTNDI LAIKNIIPTK GDIWATFEVI
  1381  ENEELERPLH YKENVLEQVL RWSSLAEPGS AYLVVKRFLT ADTIKHCSDR STLGSIKEGI
  1441  LKIKEEPSKI LSGNKFQDRY FVLRDGFLFL YKDVKSSKHD KMFSLSSMKF YRGVKKKMKP
  1501  PTSWGLTAYS EKHHWHLCCD SSRTQTEWMT SIFIAQHEYD IWPPAGKERK RSITKNPKIG
  1561  GLPLIPIQHE GNATLARKNI ESARAELERL RLSEKCDKES VDSSLKERAS MVAHCLEHKD
  1621  DKLRNRPRKH RSFNCLEDTE PEAPLGQPKG HKGLKTLRKT EDRNSKATLD SDHKLPSRVI
  1681  EELNVVLQRS RTLPKELQDE QILK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 38 nTPM
thymus: 23 nTPM
thyroid gland: 21 nTPM
cerebral cortex: 18 nTPM
skin: 15 nTPM
lymph node: 14 nTPM

Single-cell type

oligodendrocytes: 987 nCPM
bergmann glia: 863 nCPM
pituicytes/fscs: 558 nCPM
astrocytes: 501 nCPM
sertoli cells: 494 nCPM
t-cells: 340 nCPM

Immune cell

NK-cell: 6.6 nTPM
non-classical monocyte: 4.7 nTPM
gdT-cell: 3.8 nTPM
MAIT T-cell: 3.5 nTPM
memory CD8 T-cell: 2.7 nTPM
memory CD4 T-cell: 2.1 nTPM

Brain region

white matter: 213 nTPM
basal ganglia: 181 nTPM
midbrain: 128 nTPM
cerebral cortex: 125 nTPM
medulla oblongata: 119 nTPM
pons: 111 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.56
gnomAD pLI: 0
gnomAD missense Z: -0.82
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARAP2 as an antibody target. Whether an autoantibody or antibody against ARAP2 could matter depends on whether native ARAP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARAP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARAP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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