Seroatlas · Human Serome Atlas

AQP7B

Putative aquaporin-7B

Also known as: AQP7B_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A075B734
Gene
AQP7B
Canonical length
346 aa
Protein class
Metabolic proteins, Predicted membrane proteins
Quaternary structure
Homotetramer

OverviewNCBI Gene

No narrative summary is available for AQP7B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>A0A075B734|AQP7B
     1  MVQASGHRRS TRGSKMVSWS VIAKIQEIWC EEDERKMVRE FLAEFMSTYV MMVFGLGSVA
    61  HMVLNKTYGS YLGVNLGFGF GVTMGVHVAG RISGAHMNAA VTFTNCALGR VPWRKFPVHV
   121  LGQFLGSFLA AATIYSLFYT AILHFSGGEL MVTGPFATAG IFATYLPDHM TLWRGFLNEE
   181  WLTRMLQLCL FTITDQENNP ALPGTHALVI SILVVIIRVS HGINTGYAIN PSRDPPPSIF
   241  TFIAGWGKQV FSDGENWWWV PVVAPLLGAS LGGIIYLVFI GSTIPREPLK LEDSVAYEDH
   301  GITVLPKMGS HEPMISPLTL ISVSLANRSS VHSAPPLHES MALEHF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AQP7B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 30 nTPM
  • skeletal muscle: 2.5 nTPM
  • breast: 1.9 nTPM
  • heart muscle: 1.7 nTPM
  • kidney: 1.6 nTPM
  • adrenal gland: 1.3 nTPM

Single-cell type

  • adipocytes: 205 nCPM
  • schwann cells: 33 nCPM
  • retinal horizontal cells: 30 nCPM
  • proximal tubule cells: 27 nCPM
  • early spermatids: 10 nCPM
  • late spermatids: 9.4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 3.5 nTPM
  • cerebral cortex: 3.2 nTPM
  • amygdala: 2.6 nTPM
  • medulla oblongata: 2.5 nTPM
  • pons: 2.5 nTPM
  • hippocampal formation: 2.4 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AQP7B as an antibody target. Whether an autoantibody or antibody against AQP7B could matter depends on whether native AQP7B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AQP7B is annotated at the cell surface, where native AQP7B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label AQP7B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AQP7B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...