AQP7

Protein identityUniProt · HPA

UniProt accession

O14520

Gene

AQP7

Ensembl

ENSG00000165269

Chromosome

9

Canonical length

342 aa

Protein class

Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Subcellular location

Nucleoplasm,Nuclear speckles,Vesicles

Quaternary structure

Homotetramer

OverviewNCBI Gene

This gene encodes a member of the aquaporin family of water-selective membrane channels. The encoded protein localizes to the plasma membrane and allows movement of water, glycerol and urea across cell membranes. This gene is highly expressed in the adipose tissue where the encoded protein facilitates efflux of glycerol. In the proximal straight tubules of kidney, the encoded protein is localized to the apical membrane and prevents excretion of glycerol into urine. The encoded protein is present in spermatids, as well as in the testicular and epididymal spermatozoa suggesting an important role in late spermatogenesis. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. This gene is located adjacent to a related aquaporin gene on chromosome 9. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

342 residues, UniProt reviewed canonical sequence.

>O14520|AQP7
     1  MVQASGHRRS TRGSKMVSWS VIAKIQEILQ RKMVREFLAE FMSTYVMMVF GLGSVAHMVL
    61  NKKYGSYLGV NLGFGFGVTM GVHVAGRISG AHMNAAVTFA NCALGRVPWR KFPVYVLGQF
   121  LGSFLAAATI YSLFYTAILH FSGGQLMVTG PVATAGIFAT YLPDHMTLWR GFLNEAWLTG
   181  MLQLCLFAIT DQENNPALPG TEALVIGILV VIIGVSLGMN TGYAINPSRD LPPRIFTFIA
   241  GWGKQVFSNG ENWWWVPVVA PLLGAYLGGI IYLVFIGSTI PREPLKLEDS VAYEDHGITV
   301  LPKMGSHEPT ISPLTPVSVS PANRSSVHPA PPLHESMALE HF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AQP7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

6

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

200 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.95

gnomAD pLI

0

gnomAD missense Z

0.2

DepMap mean gene effect

-0.34

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• glycerol transmembrane transport
• water transport

Molecular functions

• glycerol channel activity
• urea transmembrane transporter activity
• water channel activity

Cellular components

• basolateral plasma membrane
• cell-cell junction
• cytoplasm
• cytoplasmic vesicle membrane
• lipid droplet
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Major intrinsic protein
• Aquaporin-like
• Major Intrinsic Protein/Aquaporin
• Major intrinsic protein

KeywordsUniProt

• Cell membrane
• Cytoplasmic vesicle
• Lipid droplet
• Membrane
• Phosphoprotein
• Repeat
• Transmembrane
• Transmembrane helix
• Transport

InteractionsUniProt · HPA

Protein binding partners of AQP7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PLIN1