Seroatlas · Human Serome Atlas

AQP10

Aquaporin-10

Also known as: AQP10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96PS8
Gene: AQP10
Ensembl: ENSG00000143595
Chromosome: 1
Canonical length: 301 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location: Vesicles,Plasma membrane
Quaternary structure: Homotetramer

OverviewNCBI Gene

This gene encodes a member of the aquaglyceroporin family of integral membrane proteins. Members of this family function as water-permeable channels in the epithelia of organs that absorb and excrete water. This protein was shown to function as a water-selective channel, and could also permeate neutral solutes such as glycerol and urea. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

301 residues, UniProt reviewed canonical sequence.

>Q96PS8|AQP10
     1  MVFTQAPAEI MGHLRIRSLL ARQCLAEFLG VFVLMLLTQG AVAQAVTSGE TKGNFFTMFL
    61  AGSLAVTIAI YVGGNVSGAH LNPAFSLAMC IVGRLPWVKL PIYILVQLLS AFCASGATYV
   121  LYHDALQNYT GGNLTVTGPK ETASIFATYP APYLSLNNGF LDQVLGTGML IVGLLAILDR
   181  RNKGVPAGLE PVVVGMLILA LGLSMGANCG IPLNPARDLG PRLFTYVAGW GPEVFSAGNG
   241  WWWVPVVAPL VGATVGTATY QLLVALHHPE GPEPAQDLVS AQHKASELET PASAQMLECK
   301  L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AQP10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 65 nTPM

Expression across tissuesHPA

Tissue

duodenum: 65 nTPM
small intestine: 47 nTPM
fallopian tube: 4.3 nTPM
spleen: 0.6 nTPM
stomach: 0.6 nTPM
lung: 0.5 nTPM

Single-cell type

platelets: 566 nCPM
megakaryocytes: 19 nCPM
fallopian tube ciliated cells: 16 nCPM
epididymal efferent duct ciliated cells: 4.6 nCPM
mast cells: 4.2 nCPM
foveolar cells: 3.5 nCPM

Immune cell

total PBMC: 3.3 nTPM
basophil: 0.6 nTPM
neutrophil: 0.4 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 0.4 nTPM
hippocampal formation: 0.4 nTPM
cerebral cortex: 0.3 nTPM
choroid plexus: 0.3 nTPM
amygdala: 0.2 nTPM
basal ganglia: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
gnomAD missense Z: 1.33
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AQP10 as an antibody target. Whether an autoantibody or antibody against AQP10 could matter depends on whether native AQP10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AQP10 is annotated at the cell surface, where native AQP10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label AQP10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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