Seroatlas · Human Serome Atlas

APOBEC3H

DNA dC->dU-editing enzyme APOBEC-3H

Also known as: ABC3H_HUMAN, ARP10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6NTF7
Gene
APOBEC3H
Ensembl
ENSG00000100298
Chromosome
22
Canonical length
200 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3 family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistence to human immunodeficiency virus type 1 infection in certain populations. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

200 residues, UniProt reviewed canonical sequence.

>Q6NTF7|APOBEC3H
     1  MALLTAETFR LQFNNKRRLR RPYYPRKALL CYQLTPQNGS TPTRGYFENK KKCHAEICFI
    61  NEIKSMGLDE TQCYQVTCYL TWSPCSSCAW ELVDFIKAHD HLNLGIFASR LYYHWCKPQQ
   121  KGLRLLCGSQ VPVEVMGFPE FADCWENFVD HEKPLSFNPY KMLEELDKNS RAIKRRLERI
   181  KIPGVRAQGR YMDILCDAEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APOBEC3H can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
3.6 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 3.6 nTPM
  • bone marrow: 3.4 nTPM
  • epididymis: 3.4 nTPM
  • rectum: 3.1 nTPM
  • spleen: 2.8 nTPM
  • thymus: 2.7 nTPM

Single-cell type

  • t-cells: 15 nCPM
  • nk-cells: 13 nCPM
  • hofbauer cells: 9.8 nCPM
  • cytotrophoblasts: 7.9 nCPM
  • migrating cytotrophoblasts: 6.5 nCPM
  • thymocytes: 5.1 nCPM

Immune cell

  • gdT-cell: 23 nTPM
  • NK-cell: 20 nTPM
  • memory CD8 T-cell: 19 nTPM
  • memory CD4 T-cell: 12 nTPM
  • T-reg: 12 nTPM
  • MAIT T-cell: 9.4 nTPM

Brain region

  • cerebellum: 3.2 nTPM
  • medulla oblongata: 2.6 nTPM
  • cerebral cortex: 2.5 nTPM
  • basal ganglia: 2.2 nTPM
  • white matter: 2.2 nTPM
  • midbrain: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.02
gnomAD pLI
0
gnomAD missense Z
0.02
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of APOBEC3H in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads APOBEC3H as an antibody target. Whether an autoantibody or antibody against APOBEC3H could matter depends on whether native APOBEC3H is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

APOBEC3H is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label APOBEC3H as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/APOBEC3H. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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