Seroatlas · Human Serome Atlas

APMAP

Adipocyte plasma membrane-associated protein

Also known as: APMAP_HUMAN, BSCv, C20orf3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HDC9
Gene: APMAP
Ensembl: ENSG00000101474
Chromosome: 20
Canonical length: 416 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Enables arylesterase activity. Located in cell surface and membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

416 residues, UniProt reviewed canonical sequence.

>Q9HDC9|APMAP
     1  MSEADGLRQR RPLRPQVVTD DDGQAPEAKD GSSFSGRVFR VTFLMLAVSL TVPLLGAMML
    61  LESPIDPQPL SFKEPPLLLG VLHPNTKLRQ AERLFENQLV GPESIAHIGD VMFTGTADGR
   121  VVKLENGEIE TIARFGSGPC KTRDDEPVCG RPLGIRAGPN GTLFVADAYK GLFEVNPWKR
   181  EVKLLLSSET PIEGKNMSFV NDLTVTQDGR KIYFTDSSSK WQRRDYLLLV MEGTDDGRLL
   241  EYDTVTREVK VLLDQLRFPN GVQLSPAEDF VLVAETTMAR IRRVYVSGLM KGGADLFVEN
   301  MPGFPDNIRP SSSGGYWVGM STIRPNPGFS MLDFLSERPW IKRMIFKLFS QETVMKFVPR
   361  YSLVLELSDS GAFRRSLHDP DGLVATYISE VHEHDGHLYL GSFRSPFLCR LSLQAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APMAP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 303 nTPM

Expression across tissuesHPA

Tissue

liver: 303 nTPM
thyroid gland: 196 nTPM
bone marrow: 177 nTPM
cerebellum: 162 nTPM
adipose tissue: 158 nTPM
epididymis: 100 nTPM

Single-cell type

syncytiotrophoblasts: 1,001 nCPM
neutrophil progenitors: 453 nCPM
neutrophils: 405 nCPM
cytotrophoblasts: 392 nCPM
hepatocytes: 276 nCPM
migrating cytotrophoblasts: 243 nCPM

Immune cell

neutrophil: 683 nTPM
gdT-cell: 369 nTPM
total PBMC: 363 nTPM
NK-cell: 344 nTPM
memory CD8 T-cell: 268 nTPM
MAIT T-cell: 229 nTPM

Brain region

cerebellum: 95 nTPM
hypothalamus: 89 nTPM
pons: 82 nTPM
white matter: 82 nTPM
hippocampal formation: 71 nTPM
midbrain: 70 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0
gnomAD missense Z: 0.77
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

arylesterase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Six-bladed beta-propeller, TolB-like
Strictosidine synthase, conserved region
Strictosidine synthase
Strictosidine synthase-like, N-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of APMAP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CANX

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads APMAP as an antibody target. Whether an autoantibody or antibody against APMAP could matter depends on whether native APMAP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

APMAP is annotated at the cell surface, where native APMAP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label APMAP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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