APLNR

Protein identityUniProt · HPA

UniProt accession

P35414

Gene

APLNR

Ensembl

ENSG00000134817

Chromosome

11

Canonical length

380 aa

Protein class

G-protein coupled receptors, Predicted membrane proteins, Transporters

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009]

Canonical amino-acid sequenceUniProt

380 residues, UniProt reviewed canonical sequence.

>P35414|APLNR
     1  MEEGGDFDNY YGADNQSECE YTDWKSSGAL IPAIYMLVFL LGTTGNGLVL WTVFRSSREK
    61  RRSADIFIAS LAVADLTFVV TLPLWATYTY RDYDWPFGTF FCKLSSYLIF VNMYASVFCL
   121  TGLSFDRYLA IVRPVANARL RLRVSGAVAT AVLWVLAALL AMPVMVLRTT GDLENTTKVQ
   181  CYMDYSMVAT VSSEWAWEVG LGVSSTTVGF VVPFTIMLTC YFFIAQTIAG HFRKERIEGL
   241  RKRRRLLSII VVLVVTFALC WMPYHLVKTL YMLGSLLHWP CDFDLFLMNI FPYCTCISYV
   301  NSCLNPFLYA FFDPRFRQAC TSMLCCGQSR CAGTSHSSSG EKSASYSSGH SQGPGPNMGK
   361  GGEQMHEKSI PYSQETLVVD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against APLNR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

102 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.5

gnomAD pLI

0.79

gnomAD missense Z

0.8

DepMap mean gene effect

0.02

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
• adult heart development
• angiogenesis
• aorta development
• apelin receptor signaling pathway
• atrioventricular valve development
• blood vessel development
• coronary vasculature development
• endocardial cushion formation
• G protein-coupled receptor signaling pathway
• gastrulation
• heart development
• heart looping
• negative regulation of cardiac muscle hypertrophy in response to stress
• negative regulation of gene expression
• positive regulation of angiogenesis
• positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
• positive regulation of cardiac muscle hypertrophy in response to stress
• positive regulation of G protein-coupled receptor internalization
• positive regulation of release of sequestered calcium ion into cytosol
• regulation of body fluid levels
• regulation of gene expression
• vascular associated smooth muscle cell differentiation
• vasculature development
• vasculogenesis
• venous blood vessel development
• ventricular septum morphogenesis
• negative regulation of cAMP-mediated signaling
• regulation of gap junction assembly

Molecular functions

• G protein-coupled peptide receptor activity
• G protein-coupled receptor activity
• signaling receptor activity
• apelin receptor activity
• mechanoreceptor activity

Cellular components

• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• G protein-coupled receptor, rhodopsin-like
• GPCR, rhodopsin-like, 7TM
• C-C chemokine receptor type 1-9-like
• 7 transmembrane receptor (rhodopsin family)
• Apelin receptor

KeywordsUniProt

• Angiogenesis
• Cell membrane
• Developmental protein
• Disulfide bond
• G-protein coupled receptor
• Gastrulation
• Glycoprotein
• Host-virus interaction
• Membrane
• Receptor
• Transducer
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of APLNR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• APELA