Seroatlas · Human Serome Atlas

ANOS1

Anosmin-1

Also known as: ADMLX, KAL, KAL1, KALIG-1, KALM_HUMAN, WFDC19

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P23352
Gene
ANOS1
Ensembl
ENSG00000011201
Chromosome
X
Canonical length
680 aa
Protein class
Disease related genes, Human disease related genes, Predicted secreted proteins
Secretome location
Secreted in brain

OverviewNCBI Gene

Mutations in this gene cause the X-linked Kallmann syndrome. The encoded protein is similar in sequence to proteins known to function in neural cell adhesion and axonal migration. In addition, this cell surface protein is N-glycosylated and may have anti-protease activity. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

680 residues, UniProt reviewed canonical sequence.

>P23352|ANOS1
     1  MVPGVPGAVL TLCLWLAASS GCLAAGPGAA AARRLDESLS AGSVQRARCA SRCLSLQITR
    61  ISAFFQHFQN NGSLVWCQNH KQCSKCLEPC KESGDLRKHQ CQSFCEPLFP KKSYECLTSC
   121  EFLKYILLVK QGDCPAPEKA SGFAAACVES CEVDNECSGV KKCCSNGCGH TCQVPKTLYK
   181  GVPLKPRKEL RFTELQSGQL EVKWSSKFNI SIEPVIYVVQ RRWNYGIHPS EDDATHWQTV
   241  AQTTDERVQL TDIRPSRWYQ FRVAAVNVHG TRGFTAPSKH FRSSKDPSAP PAPANLRLAN
   301  STVNSDGSVT VTIVWDLPEE PDIPVHHYKV FWSWMVSSKS LVPTKKKRRK TTDGFQNSVI
   361  LEKLQPDCDY VVELQAITYW GQTRLKSAKV SLHFTSTHAT NNKEQLVKTR KGGIQTQLPF
   421  QRRRPTRPLE VGAPFYQDGQ LQVKVYWKKT EDPTVNRYHV RWFPEACAHN RTTGSEASSG
   481  MTHENYIILQ DLSFSCKYKV TVQPIRPKSH SKAEAVFFTT PPCSALKGKS HKPVGCLGEA
   541  GHVLSKVLAK PENLSASFIV QDVNITGHFS WKMAKANLYQ PMTGFQVTWA EVTTESRQNS
   601  LPNSIISQSQ ILPSDHYVLT VPNLRPSTLY RLEVQVLTPG GEGPATIKTF RTPELPPSSA
   661  HRSHLKHRHP HHYKPSPERY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANOS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • lung: 41 nTPM
  • retina: 18 nTPM
  • cerebral cortex: 18 nTPM
  • parathyroid gland: 14 nTPM
  • skeletal muscle: 9.8 nTPM
  • basal ganglia: 9 nTPM

Single-cell type

  • alveolar cells type 1: 340 nCPM
  • respiratory basal cells: 288 nCPM
  • medullary thymic epithelial cells: 206 nCPM
  • microglia: 187 nCPM
  • astrocytes: 155 nCPM
  • sertoli cells: 120 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • spinal cord: 41 nTPM
  • white matter: 38 nTPM
  • pons: 34 nTPM
  • medulla oblongata: 32 nTPM
  • hypothalamus: 29 nTPM
  • midbrain: 27 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ANOS1.

Disease | AllUniProt

Conditions ANOS1 is implicated in, by any mechanism.

  • Hypogonadotropic hypogonadism 1 with or without anosmia (HH1) MIM:308700

Disease | GeneticClinVar

95 pathogenic / likely-pathogenic of 480 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.25
gnomAD pLI
1
DepMap mean gene effect
0.23
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANOS1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANOS1 as an antibody target. Whether an autoantibody or antibody against ANOS1 could matter depends on whether native ANOS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANOS1 is annotated at the cell surface, where native ANOS1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ANOS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ANOS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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