Seroatlas · Human Serome Atlas

ANLN

Anillin

Also known as: ANILLIN, ANLN_HUMAN, scra, Scraps

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NQW6
Gene: ANLN
Ensembl: ENSG00000011426
Chromosome: 7
Canonical length: 1124 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Midbody

OverviewNCBI Gene

This gene encodes an actin-binding protein that plays a role in cell growth and migration, and in cytokinesis. The encoded protein is thought to regulate actin cytoskeletal dynamics in podocytes, components of the glomerulus. Mutations in this gene are associated with focal segmental glomerulosclerosis 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

Canonical amino-acid sequenceUniProt

1124 residues, UniProt reviewed canonical sequence.

>Q9NQW6|ANLN
     1  MDPFTEKLLE RTRARRENLQ RKMAERPTAA PRSMTHAKRA RQPLSEASNQ QPLSGGEEKS
    61  CTKPSPSKKR CSDNTEVEVS NLENKQPVES TSAKSCSPSP VSPQVQPQAA DTISDSVAVP
   121  ASLLGMRRGL NSRLEATAAS SVKTRMQKLA EQRRRWDNDD MTDDIPESSL FSPMPSEEKA
   181  ASPPRPLLSN ASATPVGRRG RLANLAATIC SWEDDVNHSF AKQNSVQEQP GTACLSKFSS
   241  ASGASARINS SSVKQEATFC SQRDGDASLN KALSSSADDA SLVNASISSS VKATSPVKST
   301  TSITDAKSCE GQNPELLPKT PISPLKTGVS KPIVKSTLSQ TVPSKGELSR EICLQSQSKD
   361  KSTTPGGTGI KPFLERFGER CQEHSKESPA RSTPHRTPII TPNTKAIQER LFKQDTSSST
   421  THLAQQLKQE RQKELACLRG RFDKGNIWSA EKGGNSKSKQ LETKQETHCQ STPLKKHQGV
   481  SKTQSLPVTE KVTENQIPAK NSSTEPKGFT ECEMTKSSPL KITLFLEEDK SLKVTSDPKV
   541  EQKIEVIREI EMSVDDDDIN SSKVINDLFS DVLEEGELDM EKSQEEMDQA LAESSEEQED
   601  ALNISSMSLL APLAQTVGVV SPESLVSTPR LELKDTSRSD ESPKPGKFQR TRVPRAESGD
   661  SLGSEDRDLL YSIDAYRSQR FKETERPSIK QVIVRKEDVT SKLDEKNNAF PCQVNIKQKM
   721  QELNNEINMQ QTVIYQASQA LNCCVDEEHG KGSLEEAEAE RLLLIATGKR TLLIDELNKL
   781  KNEGPQRKNK ASPQSEFMPS KGSVTLSEIR LPLKADFVCS TVQKPDAANY YYLIILKAGA
   841  ENMVATPLAS TSNSLNGDAL TFTTTFTLQD VSNDFEINIE VYSLVQKKDP SGLDKKKKTS
   901  KSKAITPKRL LTSITTKSNI HSSVMASPGG LSAVRTSNFA LVGSYTLSLS SVGNTKFVLD
   961  KVPFLSSLEG HIYLKIKCQV NSSVEERGFL TIFEDVSGFG AWHRRWCVLS GNCISYWTYP
  1021  DDEKRKNPIG RINLANCTSR QIEPANREFC ARRNTFELIT VRPQREDDRE TLVSQCRDTL
  1081  CVTKNWLSAD TKEERDLWMQ KLNQVLVDIR LWQPDACYKP IGKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANLN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 163 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 163 nTPM
midbrain: 73 nTPM
hippocampal formation: 55 nTPM
cerebral cortex: 48 nTPM
bone marrow: 34 nTPM
amygdala: 32 nTPM

Single-cell type

oligodendrocytes: 484 nCPM
monocyte progenitors: 259 nCPM
early spermatids: 185 nCPM
neutrophil progenitors: 135 nCPM
late primary spermatocytes: 96 nCPM
erythrocyte progenitors: 92 nCPM

Immune cell

T-reg: 0.3 nTPM
total PBMC: 0.3 nTPM
classical monocyte: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
neutrophil: 0.1 nTPM

Brain region

white matter: 514 nTPM
medulla oblongata: 320 nTPM
basal ganglia: 253 nTPM
pons: 241 nTPM
cerebellum: 240 nTPM
midbrain: 200 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ANLN.

Disease | AllUniProt

Conditions ANLN is implicated in, by any mechanism.

Focal segmental glomerulosclerosis 8 (FSGS8) MIM:616032

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 605 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Focal segmental glomerulosclerosis 8

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.37
gnomAD pLI: 0.14
gnomAD missense Z: 0.9
DepMap mean gene effect: -0.64
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Pleckstrin homology domain
PH-like domain superfamily
Anillin homology domain
Cytokinesis and Rho signaling-related protein
PH domain
Cell division protein anillin
Anillin, N-terminal domain
Anillin, PH domain
Anillin N-terminus

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANLN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANLN as an antibody target. Whether an autoantibody or antibody against ANLN could matter depends on whether native ANLN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANLN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANLN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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