Seroatlas · Human Serome Atlas

ANKRD40

Ankyrin repeat domain-containing protein 40

Also known as: ANR40_HUMAN, MGC15396

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6AI12
Gene: ANKRD40
Ensembl: ENSG00000154945
Chromosome: 17
Canonical length: 368 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli fibrillar center,Golgi apparatus,Cytosol

OverviewNCBI Gene

No narrative summary is available for ANKRD40 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

368 residues, UniProt reviewed canonical sequence.

>Q6AI12|ANKRD40
     1  MNALLEQKEQ QERLREAAAL GDIREVQKLV ESGVDVNSQN EVNGWTCLHW ACKRNHGQVV
    61  SYLLKSGADK EILTTKGEMP VQLTSRREIR KIMGVEEEDD DDDDDDNLPQ LKKESELPFV
   121  PNYLANPAFP FIYTPTAEDS AQMQNGGPST PPASPPADGS PPLLPPGEPP LLGTFPRDHT
   181  SLALVQNGDV SAPSAILRTP ESTKPGPVCQ PPVSQSRSLF SSVPSKPPMS LEPQNGTYAG
   241  PAPAFQPFFF TGAFPFNMQE LVLKVRIQNP SLRENDFIEI ELDRQELTYQ ELLRVCCCEL
   301  GVNPDQVEKI RKLPNTLLRK DKDVARLQDF QELELVLMIS ENNFLFRNAA STLTERPCYN
   361  RRASKLTY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKRD40 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 196 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 196 nTPM
midbrain: 160 nTPM
hippocampal formation: 105 nTPM
basal ganglia: 101 nTPM
skeletal muscle: 100 nTPM
amygdala: 97 nTPM

Single-cell type

myonuclei: 64 nCPM
smooth muscle cells: 58 nCPM
alveolar cells type 1: 52 nCPM
thymic myoid cells: 50 nCPM
kupffer cells: 47 nCPM
peritubular myoid cells: 43 nCPM

Immune cell

plasmacytoid DC: 14 nTPM
naive CD8 T-cell: 13 nTPM
MAIT T-cell: 13 nTPM
memory CD8 T-cell: 12 nTPM
non-classical monocyte: 12 nTPM
memory CD4 T-cell: 12 nTPM

Brain region

white matter: 249 nTPM
basal ganglia: 249 nTPM
midbrain: 228 nTPM
medulla oblongata: 226 nTPM
spinal cord: 209 nTPM
thalamus: 198 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.56
gnomAD pLI: 0.25
gnomAD missense Z: 1.21
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ANKRD40 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKRD40 as an antibody target. Whether an autoantibody or antibody against ANKRD40 could matter depends on whether native ANKRD40 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKRD40 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKRD40 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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