Seroatlas · Human Serome Atlas

ANKDD1B

Ankyrin repeat and death domain-containing protein 1B

Also known as: AKD1B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NHY2
Gene: ANKDD1B
Ensembl: ENSG00000189045
Chromosome: 5
Canonical length: 528 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in signal transduction. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

528 residues, UniProt reviewed canonical sequence.

>A6NHY2|ANKDD1B
     1  MDPAGRARGQ GATAGGLLLR AAAAAKGLRE DLWGAAALPW RSLSRIPKRE GLGEEDTAVA
    61  GHELLLPNER SFQNAAKSNN LDLMEKLFEK KVNINVVNNM NRTALHFAVG RNHLSAVDFL
   121  LKHKARVDVA DKHGLTVIHL AAWSGSLEVM LMLVKAGADQ RAKNQDGMSA LHFATQSNHV
   181  RIVEYLIQDL HLKDLNQPDE KGRKPFLLAA ERGHVEMIEK LTFLNLHTSE KDKGGNTALH
   241  LAAKHGHSPA VQVLLAQWQD INEMNELNIS SLQIATRNGH ASLVNFLLSE NVDLHQKVEP
   301  KESPLHLVVI NNHITVVNSL LSAQHDIDIL NQKQQTPLHV AADRGNVELV ETLLKAGCDL
   361  KAVDKQGKTA LAVASRSNHS LVVGMLIKAE RYYAWREEHH ESIRDPSTGF TLTFKQDHSL
   421  ETRHIRTLLW DLAYHQLKAN EWQRLARSWN FTDDQIRAIE EQWSGNESFR EHGHRALLIW
   481  LHGTLMTQGD PAKQLYEELV HAGFPKLAEK TRHFKSKTDS NSKKCVVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKDD1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 4.1 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 4.1 nTPM
kidney: 3.3 nTPM
colon: 3.2 nTPM
rectum: 3.1 nTPM
stomach: 1.8 nTPM
skin: 1.6 nTPM

Single-cell type

ependymal cells: 259 nCPM
respiratory ciliated cells: 174 nCPM
choroid plexus epithelial cells: 144 nCPM
fallopian tube ciliated cells: 134 nCPM
epididymal efferent duct ciliated cells: 103 nCPM
endometrial ciliated cells: 85 nCPM

Immune cell

NK-cell: 0.5 nTPM
T-reg: 0.3 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

choroid plexus: 6.7 nTPM
midbrain: 4.5 nTPM
basal ganglia: 3.5 nTPM
hypothalamus: 3.5 nTPM
medulla oblongata: 3.5 nTPM
spinal cord: 3.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.03
gnomAD pLI: 0
gnomAD missense Z: 1.54
DepMap mean gene effect: 0.12
DepMap dependency class: selective

OntologyGO

Biological processes

signal transduction

Protein domainsUniProt · Pfam · InterPro

Death domain
Ankyrin repeat
Death-like domain superfamily
Ankyrin repeat-containing domain superfamily
Ankyrin repeat
Ankyrin repeats (3 copies)
Ankyrin repeat and death domain-containing protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKDD1B as an antibody target. Whether an autoantibody or antibody against ANKDD1B could matter depends on whether native ANKDD1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKDD1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKDD1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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