Seroatlas · Human Serome Atlas

ANKDD1A

Ankyrin repeat and death domain-containing protein 1A

Also known as: AKD1A_HUMAN, FLJ25870

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q495B1
Gene: ANKDD1A
Ensembl: ENSG00000166839
Chromosome: 15
Canonical length: 522 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in signal transduction. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

522 residues, UniProt reviewed canonical sequence.

>Q495B1|ANKDD1A
     1  MQEELAWETD GLLPLERQLH EAARQNNVGR MQELIGRRVN TRARNHVGRV ALHWAAGAGH
    61  EQAVRLLLEH EAAVDEEDAV GALTEARLCF GMNALLLSAW FGHLRILQIL VNSGAKIHCE
   121  SKDGLTLLHC AAQKGHVPVL AFIMEDLEDV ALDHVDKLGR TAFHRAAEHG QLDALDFLVG
   181  SGCDHNVKDK EGNTALHLAA GRGHMAVLQR LVDIGLDLEE QNAEGLTALH SAAGGSHPDC
   241  VQLLLRAGST VNALTQKNLS CLHYAALSGS EDVSRVLIHA GGCANVVDHQ GASPLHLAVR
   301  HNFPALVRLL INSDSDVNAV DNRQQTPLHL AAEHAWQDIA DMLLIAGVDL NLRDKQGKTA
   361  LAVAVRSNHV SLVDMIIKAD RFYRWEKDHP SDPSGKSLSF KQDHRQETQQ LRSVLWRLAS
   421  RYLQPREWKK LAYSWEFTEA HVDAIEQQWT GTRSYQEHGH RMLLIWLHGV ATAGENPSKA
   481  LFEGLVAIGR RDLAGWSTMA RSQLTATSAS RVQMILVPQP PE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ANKDD1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 7.9 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 7.9 nTPM
blood vessel: 6.5 nTPM
spleen: 4.9 nTPM
parathyroid gland: 4.3 nTPM
adipose tissue: 3.2 nTPM
pancreas: 2.9 nTPM

Single-cell type

bergmann glia: 415 nCPM
astrocytes: 291 nCPM
peritubular myoid cells: 155 nCPM
epicardial cells: 146 nCPM
leydig cells: 130 nCPM
adrenal cortex cells: 119 nCPM

Immune cell

NK-cell: 3.1 nTPM
T-reg: 2 nTPM
memory CD8 T-cell: 1.3 nTPM
intermediate monocyte: 0.9 nTPM
gdT-cell: 0.8 nTPM
non-classical monocyte: 0.8 nTPM

Brain region

medulla oblongata: 9.4 nTPM
cerebral cortex: 9.3 nTPM
basal ganglia: 7.1 nTPM
thalamus: 7.1 nTPM
amygdala: 6.6 nTPM
hippocampal formation: 6.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0
gnomAD missense Z: 0.65
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ANKDD1A as an antibody target. Whether an autoantibody or antibody against ANKDD1A could matter depends on whether native ANKDD1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ANKDD1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ANKDD1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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