ANHX
Anomalous homeobox protein
Also known as: ANHX_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- E9PGG2
- Gene
- ANHX
- Ensembl
- ENSG00000227059
- Chromosome
- 12
- Canonical length
- 379 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of skeletal muscle cell proliferation; regulation of transcription by RNA polymerase II; and skeletal muscle fiber development. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
379 residues, UniProt reviewed canonical sequence.
>E9PGG2|ANHX
1 MQSFLTLLKE HEDTCAPPAE LVTLAGRLCR DFQDDLAQLQ PLVTAILDSQ LRLHLLDNAD
61 VALACARVLD QQEQQQAACR LLEGCQVPGG SQELVQLWND IHYRLVMRRL GVAALTPVQK
121 FRCRKRNPPP PSLCPEGLKS RNFPREVREK LHNFAVGVNT NPSKAERENL ALETSLTPEQ
181 VYNWFANYRR RQRALPQHMK PAQQATAEDP GARERGPDLL QPSGNPRVDS GFVDRPQWSE
241 EREEKGPPQS PQTTQGPWEP LALAPDFPAD ETVSKPLDVS GHPQSVQLEE GLGTSSGRTE
301 LRVGSFLVTQ PPLQAPEFIL TQSPPELAPA PSAFPGPVSA MELSQALPSS QVQCSDSQAS
361 GDAFWGARML LEFSGSSLGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ANHX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.51
- Highest tissue expression
- 5.7 nTPM
Expression across tissuesHPA
Tissue
- testis: 5.7 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
Single-cell type
- differentiating spermatogonia: 34 nCPM
- undifferentiated spermatogonia: 19 nCPM
- early primary spermatocytes: 18 nCPM
- late primary spermatocytes: 0.9 nCPM
- late spermatids: 0.6 nCPM
- basal prostatic cells: 0.3 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- basal ganglia: 0.3 nTPM
- cerebral cortex: 0.1 nTPM
- choroid plexus: 0.1 nTPM
- amygdala: 0 nTPM
- cerebellum: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.58
- gnomAD pLI
- 0.23
- gnomAD missense Z
- 1.17
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
OntologyGO
Biological processes
- regulation of skeletal muscle cell proliferation
- regulation of transcription by RNA polymerase II
- skeletal muscle fiber development
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ANHX as an antibody target. Whether an autoantibody or antibody against ANHX could matter depends on whether native ANHX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ANHX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ANHX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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