Homeobox protein SIX1, N-terminal SD domain

Definition

The SD domain is found N-terminal to the homeobox domain in the protein SIX1. As a transcription factor, SIX1 lacks intrinsic activation domains and thus needs to bind to the EYA family of co-factors in order to mediate transcriptional activation. The SD domain is necessary for this protein-protein interaction, binding to the C-terminal region of EYA (Eyes absent homologue proteins) PMID:23435380.

7 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (7 proteins: gene, accession, name)

• ANHX
• SIX1
• SIX2
• SIX3
• SIX4
• SIX5
• SIX6