Seroatlas · Human Serome Atlas

ALG10B

Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

Also known as: AG10B_HUMAN, KCR1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5I7T1
Gene: ALG10B
Ensembl: ENSG00000175548
Chromosome: 12
Canonical length: 473 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location: Endoplasmic reticulum

OverviewNCBI Gene

Enables dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity. Involved in dolichol-linked oligosaccharide biosynthetic process. Located in plasma membrane. Is active in endoplasmic reticulum membrane. Implicated in long QT syndrome 2. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

473 residues, UniProt reviewed canonical sequence.

>Q5I7T1|ALG10B
     1  MAQLEGYCFS AALSCTFLVS CLLFSAFSRA LREPYMDEIF HLPQAQRYCE GHFSLSQWDP
    61  MITTLPGLYL VSVGVVKPAI WIFAWSEHVV CSIGMLRFVN LLFSVGNFYL LYLLFHKVQP
   121  RNKAASSIQR VLSTLTLAVF PTLYFFNFLY YTEAGSMFFT LFAYLMCLYG NHKTSAFLGF
   181  CGFMFRQTNI IWAVFCAGNV IAQKLTEAWK TELQKKEDRL PPIKGPFAEF RKILQFLLAY
   241  SMSFKNLSML FCLTWPYILL GFLFCAFVVV NGGIVIGDRS SHEACLHFPQ LFYFFSFTLF
   301  FSFPHLLSPS KIKTFLSLVW KHGILFLVVT LVSVFLVWKF TYAHKYLLAD NRHYTFYVWK
   361  RVFQRYAILK YLLVPAYIFA GWSIADSLKS KPIFWNLMFF ICLFIVIVPQ KLLEFRYFIL
   421  PYVIYRLNIT LPPTSRLVCE LSCYAIVNFI TFYIFLNKTF QWPNSQDIQR FMW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ALG10B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 8.4 nTPM

Expression across tissuesHPA

Tissue

retina: 8.4 nTPM
breast: 4.8 nTPM
placenta: 4.7 nTPM
spleen: 4.4 nTPM
lymph node: 4.3 nTPM
skin: 4.1 nTPM

Single-cell type

cytotrophoblasts: 18 nCPM
migrating cytotrophoblasts: 18 nCPM
gastric chief cells: 15 nCPM
hematopoietic stem cells: 14 nCPM
ependymal cells: 14 nCPM
thymic myoid cells: 14 nCPM

Immune cell

naive B-cell: 1.3 nTPM
T-reg: 1.2 nTPM
naive CD8 T-cell: 0.7 nTPM
plasmacytoid DC: 0.7 nTPM
eosinophil: 0.6 nTPM
intermediate monocyte: 0.5 nTPM

Brain region

white matter: 9.7 nTPM
cerebellum: 9.6 nTPM
spinal cord: 9.1 nTPM
medulla oblongata: 8.8 nTPM
midbrain: 8.3 nTPM
thalamus: 8.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
gnomAD missense Z: -1.57
DepMap mean gene effect: -0.36
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

2-glucosyltransferase activity
dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ALG10B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ALG10B as an antibody target. Whether an autoantibody or antibody against ALG10B could matter depends on whether native ALG10B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ALG10B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ALG10B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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