Seroatlas · Human Serome Atlas

AGR3

Anterior gradient protein 3

Also known as: AGR3_HUMAN, BCMP11, hAG-3, HAG3, PDIA18

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TD06
Gene
AGR3
Ensembl
ENSG00000173467
Chromosome
7
Canonical length
166 aa
Protein class
Predicted intracellular proteins
Subcellular location
Endoplasmic reticulum,Vesicles
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This gene is expressed in ciliated airway epithelial cells and, in mouse, plays a role in ciliary beat frequency in multiciliated cells. This gene is also over-expressed in breast, ovarian, and prostrate cancers. [provided by RefSeq, Dec 2016]

Canonical amino-acid sequenceUniProt

166 residues, UniProt reviewed canonical sequence.

>Q8TD06|AGR3
     1  MMLHSALGLC LLLVTVSSNL AIAIKKEKRP PQTLSRGWGD DITWVQTYEE GLFYAQKSKK
    61  PLMVIHHLED CQYSQALKKV FAQNEEIQEM AQNKFIMLNL MHETTDKNLS PDGQYVPRIM
   121  FVDPSLTVRA DIAGRYSNRL YTYEPRDLPL LIENMKKALR LIQSEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AGR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
224 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 224 nTPM
  • fallopian tube: 211 nTPM
  • colon: 206 nTPM
  • rectum: 201 nTPM
  • duodenum: 157 nTPM
  • lung: 144 nTPM

Single-cell type

  • fallopian tube ciliated cells: 1,359 nCPM
  • enterocytes: 1,251 nCPM
  • respiratory ciliated cells: 1,173 nCPM
  • endometrial ciliated cells: 987 nCPM
  • transitional alveolar cells: 887 nCPM
  • goblet cells: 846 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • midbrain: 7 nTPM
  • medulla oblongata: 4.3 nTPM
  • spinal cord: 1.4 nTPM
  • white matter: 1 nTPM
  • hypothalamus: 0.8 nTPM
  • pons: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.98
gnomAD pLI
0
gnomAD missense Z
-0.9
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AGR3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AGR3 as an antibody target. Whether an autoantibody or antibody against AGR3 could matter depends on whether native AGR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AGR3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AGR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AGR3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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