Seroatlas · Human Serome Atlas

AGPAT1

1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

Also known as: LPAAT-alpha, LPLAT1, PLCA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q99943
Gene
AGPAT1
Ensembl
ENSG00000204310
Chromosome
6
Canonical length
283 aa
Protein class
Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location
Endoplasmic reticulum,Rods & Rings

OverviewNCBI Gene

This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

283 residues, UniProt reviewed canonical sequence.

>Q99943|AGPAT1
     1  MDLWPGAWML LLLLFLLLLF LLPTLWFCSP SAKYFFKMAF YNGWILFLAV LAIPVCAVRG
    61  RNVENMKILR LMLLHIKYLY GIRVEVRGAH HFPPSQPYVV VSNHQSSLDL LGMMEVLPGR
   121  CVPIAKRELL WAGSAGLACW LAGVIFIDRK RTGDAISVMS EVAQTLLTQD VRVWVFPEGT
   181  RNHNGSMLPF KRGAFHLAVQ AQVPIVPIVM SSYQDFYCKK ERRFTSGQCQ VRVLPPVPTE
   241  GLTPDDVPAL ADRVRHSMLT VFREISTDGR GGGDYLKKPG GGG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AGPAT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
92 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 92 nTPM
  • testis: 77 nTPM
  • hippocampal formation: 74 nTPM
  • basal ganglia: 73 nTPM
  • amygdala: 68 nTPM
  • hypothalamus: 66 nTPM

Single-cell type

  • other brain neurons: 25 nCPM
  • brain inhibitory neurons: 23 nCPM
  • oligodendrocytes: 22 nCPM
  • ependymal cells: 20 nCPM
  • oligodendrocyte progenitor cells: 19 nCPM
  • brain excitatory neurons: 18 nCPM

Immune cell

  • eosinophil: 13 nTPM
  • plasmacytoid DC: 12 nTPM
  • myeloid DC: 9.4 nTPM
  • neutrophil: 9.4 nTPM
  • NK-cell: 8.7 nTPM
  • memory CD8 T-cell: 8.6 nTPM

Brain region

  • hypothalamus: 65 nTPM
  • midbrain: 24 nTPM
  • cerebral cortex: 22 nTPM
  • white matter: 11 nTPM
  • pons: 9.7 nTPM
  • basal ganglia: 8.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.31
gnomAD pLI
0.97
gnomAD missense Z
2.61
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AGPAT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AGPAT1 as an antibody target. Whether an autoantibody or antibody against AGPAT1 could matter depends on whether native AGPAT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AGPAT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AGPAT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AGPAT1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...