Seroatlas · Human Serome Atlas

ADCK5

Uncharacterized aarF domain-containing protein kinase 5

Also known as: ADCK5_HUMAN, FLJ35454

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3MIX3
Gene: ADCK5
Ensembl: ENSG00000173137
Chromosome: 8
Canonical length: 580 aa
Protein class: Enzymes, Predicted membrane proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable protein serine/threonine kinase activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

580 residues, UniProt reviewed canonical sequence.

>Q3MIX3|ADCK5
     1  MWRPVQLCHF HSALLHSRQK PWPSPAVFFR RNVRGLPPRF SSPTPLWRKV LSTAVVGAPL
    61  LLGARYVMAE AREKRRMRLV VDGMGRFGRS LKVGLQISLD YWWCTNVVLR GVEENSPGYL
   121  EVMSACHQRA ADALVAGAIS NGGLYVKLGQ GLCSFNHLLP PEYTRTLRVL EDRALKRGFQ
   181  EVDELFLEDF QALPHELFQE FDYQPIAAAS LAQVHRAKLH DGTSVAVKVQ YIDLRDRFDG
   241  DIHTLELLLR LVEVMHPSFG FSWVLQDLKG TLAQELDFEN EGRNAERCAR ELAHFPYVVV
   301  PRVHWDKSSK RVLTADFCAG CKVNDVEAIR SQGLAVHDIA EKLIKAFAEQ IFYTGFIHSD
   361  PHPGNVLVRK GPDGKAELVL LDHGLYQFLE EKDRAALCQL WRAIILRDDA AMRAHAAALG
   421  VQDYLLFAEM LMQRPVRLGQ LWGSHLLSRE EAAYMVDMAR ERFEAVMAVL RELPRPMLLV
   481  LRNINTVRAI NVALGAPVDR YFLMAKRAVR GWSRLAGATY RGVYGTSLLR HAKVVWEMLK
   541  FEVALRLETL AMRLTALLAR ALVHLSLVPP AEELYQYLET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADCK5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 9.1 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 9.1 nTPM
small intestine: 8 nTPM
cerebellum: 6.7 nTPM
testis: 6.6 nTPM
colon: 6.5 nTPM
liver: 6.4 nTPM

Single-cell type

enterocytes: 37 nCPM
early primary spermatocytes: 27 nCPM
enteric stem cells: 17 nCPM
goblet cells: 16 nCPM
paneth cells: 16 nCPM
enteric transient amplifying cells: 14 nCPM

Immune cell

myeloid DC: 3.2 nTPM
intermediate monocyte: 2.7 nTPM
naive B-cell: 2.7 nTPM
non-classical monocyte: 2.7 nTPM
T-reg: 2.1 nTPM
classical monocyte: 2 nTPM

Brain region

cerebral cortex: 2.3 nTPM
medulla oblongata: 2.1 nTPM
basal ganglia: 1.9 nTPM
hippocampal formation: 1.9 nTPM
pons: 1.9 nTPM
white matter: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0
gnomAD missense Z: 2.18
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

protein serine/threonine kinase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADCK5 as an antibody target. Whether an autoantibody or antibody against ADCK5 could matter depends on whether native ADCK5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADCK5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ADCK5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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