Seroatlas · Human Serome Atlas

ADCK2

Uncharacterized aarF domain-containing protein kinase 2

Also known as: ADCK2_HUMAN, MGC20727

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z695
Gene: ADCK2
Ensembl: ENSG00000133597
Chromosome: 7
Canonical length: 626 aa
Protein class: Enzymes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Centrosome,Cytosol

OverviewNCBI Gene

Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Involved in regulation of ubiquinone biosynthetic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

626 residues, UniProt reviewed canonical sequence.

>Q7Z695|ADCK2
     1  MVAPWRVSVR VCLSHLRCFE LRQGLSLLRP SECPRDARLC WLLLGTLPKV VSLCGDVGEG
    61  APDVLSRRRV RCSGAAGAGP AESLPRAGPL GGVFLHLRLW LRAGALLVKF FPLLLLYPLT
   121  YLAPSVSTLW LHLLLKATET SGPTYIKLGQ WASTRRDLFS EAFCAQFSKL HVRVTPHPWT
   181  HTERFLRQAF GDDWGSILSF ENREPVGSGC VAQVYKAYAN TAFLETDSVQ RLGRASCLPP
   241  FSHTGAVGGL RELFGYLGNG RKPPENLADQ SFLERLLLPK ADLVGSNAGV SRAQVPGHQP
   301  EATNLISVAV KVLHPGLLAQ VHMDLLLMKI GSRVLGVLPG IKWLSLPEIV EEFEKLMVQQ
   361  IDLRYEAQNL EHFQVNFRNV KAVKFPTPLR PFVTREVLVE TYEESVPVSS YQQAGIPVDL
   421  KRKIARLGIN MLLKMIFVDN FVHADLHPGN ILVQGANGLS SSQEAQLQQA DICDTLVVAV
   481  PSSLCPLRLV LLDAGIVAEL QAPDLRNFRA VFMAVVMGQG QRVAELILHH ARASECRDVE
   541  GFKTEMAMLV TQARKNTITL EKLHVSSLLS SVFKLLMTHK VKLESNFASI VFAIMVLEGL
   601  GRSLDPKLDI LEAARPFLLT GPVCPP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADCK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

skin: 25 nTPM
spinal cord: 25 nTPM
midbrain: 19 nTPM
cerebral cortex: 19 nTPM
parathyroid gland: 18 nTPM
hypothalamus: 17 nTPM

Single-cell type

late spermatids: 16 nCPM
microglia: 11 nCPM
early spermatids: 10 nCPM
epicardial cells: 9.1 nCPM
late primary spermatocytes: 7.3 nCPM
syncytiotrophoblasts: 7.3 nCPM

Immune cell

plasmacytoid DC: 10 nTPM
memory B-cell: 7 nTPM
naive CD4 T-cell: 5.8 nTPM
T-reg: 5.4 nTPM
myeloid DC: 4.8 nTPM
NK-cell: 4.5 nTPM

Brain region

white matter: 40 nTPM
medulla oblongata: 37 nTPM
spinal cord: 32 nTPM
thalamus: 31 nTPM
pons: 31 nTPM
cerebral cortex: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0
gnomAD missense Z: 0.92
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of ubiquinone biosynthetic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADCK2 as an antibody target. Whether an autoantibody or antibody against ADCK2 could matter depends on whether native ADCK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADCK2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ADCK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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