Seroatlas · Human Serome Atlas

ADCK1

AarF domain-containing protein kinase 1

Also known as: ADCK1_HUMAN, FLJ39600

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86TW2
Gene: ADCK1
Ensembl: ENSG00000063761
Chromosome: 14
Canonical length: 530 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Involved in negative regulation of mitochondrial fusion and positive regulation of cristae formation. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

530 residues, UniProt reviewed canonical sequence.

>Q86TW2|ADCK1
     1  MARKALKLAS WTSMALAASG IYFYSNKYLD PNDFGAVRVG RAVATTAVIS YDYLTSLKSV
    61  PYGSEEYLQL RSKSWPVFLQ VHLRSARRLC ELCCANRGTF IKVGQHLGAL DYLLPEEYTS
   121  TLKVLHSQAP QSSMQEIRQV IREDLGKEIH DLFQSFDDTP LGTASLAQVH KAVLHDGRTV
   181  AVKVQHPKVR AQSSKDILLM EVLVLAVKQL FPEFEFMWLV DEAKKNLPLE LDFLNEGRNA
   241  EKVSQMLRHF DFLKVPRIHW DLSTERVLLM EFVDGGQVND RDYMERNKID VNEISRHLGK
   301  MYSEMIFVNG FVHCDPHPGN VLVRKHPGTG KAEIVLLDHG LYQMLTEEFR LNYCHLWQSL
   361  IWTDMKRVKE YSQRLGAGDL YPLFACMLTA RSWDSVNRGI SQAPVTATED LEIRNNAANY
   421  LPQISHLLNH VPRQMLLILK TNDLLRGIEA ALGTRASASS FLNMSRCCIR ALAEHKKKNT
   481  CSFFRRTQIS FSEAFNLWQI NLHELILRVK GLKLADRVLA LICWLFPAPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADCK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 11 nTPM
heart muscle: 10 nTPM
choroid plexus: 10 nTPM
hippocampal formation: 9.9 nTPM
cerebral cortex: 9.8 nTPM
adrenal gland: 9.7 nTPM

Single-cell type

cone photoreceptor cells: 62 nCPM
choroid plexus epithelial cells: 54 nCPM
erythrocyte progenitors: 51 nCPM
myonuclei: 39 nCPM
oligodendrocytes: 37 nCPM
rod photoreceptor cells: 35 nCPM

Immune cell

myeloid DC: 7.5 nTPM
intermediate monocyte: 6 nTPM
plasmacytoid DC: 5.5 nTPM
gdT-cell: 4.2 nTPM
classical monocyte: 4 nTPM
naive CD8 T-cell: 3.4 nTPM

Brain region

white matter: 13 nTPM
cerebral cortex: 10 nTPM
choroid plexus: 9.5 nTPM
pons: 9.2 nTPM
thalamus: 8.7 nTPM
hippocampal formation: 8.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0
gnomAD missense Z: -0.3
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADCK1 as an antibody target. Whether an autoantibody or antibody against ADCK1 could matter depends on whether native ADCK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADCK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ADCK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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