ABITRAM
Protein Abitram
Also known as: ABITM_HUMAN, C9orf6, CG-8, FAM206A, FLJ20457, Simiate
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NX38
- Gene
- ABITRAM
- Ensembl
- ENSG00000119328
- Chromosome
- 9
- Canonical length
- 181 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Kinetochore,Cytokinetic bridge,Mitotic spindle,Primary cilium,Primary cilium tip,Basal body,Cytosol
OverviewNCBI Gene
Predicted to enable actin filament binding activity and actin monomer binding activity. Predicted to be involved in dendrite morphogenesis; regulation of actin filament polymerization; and regulation of filopodium assembly. Predicted to be located in growth cone. Predicted to be active in several cellular components, including dendrite; filopodium tip; and lamellipodium. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
181 residues, UniProt reviewed canonical sequence.
>Q9NX38|ABITRAM
1 MATEPEAAEP VVPSLVDRYF TRWYKPDVKG KFCEDHCILQ HSNRICVITL AESHPVLQSG
61 KTIKSISYQI STNCSRLQNK VSGKFKRGAQ FLTELAPLCK IYCSDGEEYT VSSCVRGRLM
121 EVNENILHKP SILQEKPSTE GYIAVVLPKF EESKSITEGL LTQKQYEEVM VKRINATTAT
181 SLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ABITRAM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.32
- Highest tissue expression
- 24 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 24 nTPM
- skin: 23 nTPM
- retina: 23 nTPM
- parathyroid gland: 22 nTPM
- fallopian tube: 20 nTPM
- basal ganglia: 19 nTPM
Single-cell type
- epicardial cells: 127 nCPM
- respiratory ciliated cells: 63 nCPM
- fallopian tube ciliated cells: 56 nCPM
- endometrial ciliated cells: 51 nCPM
- cardiomyocytes: 50 nCPM
- ependymal cells: 45 nCPM
Immune cell
- basophil: 39 nTPM
- neutrophil: 38 nTPM
- plasmacytoid DC: 37 nTPM
- myeloid DC: 36 nTPM
- non-classical monocyte: 35 nTPM
- intermediate monocyte: 34 nTPM
Brain region
- cerebral cortex: 21 nTPM
- choroid plexus: 20 nTPM
- basal ganglia: 20 nTPM
- white matter: 19 nTPM
- thalamus: 18 nTPM
- spinal cord: 18 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.47
- gnomAD pLI
- 0
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ABITRAM in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ABITRAM as an antibody target. Whether an autoantibody or antibody against ABITRAM could matter depends on whether native ABITRAM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ABITRAM is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ABITRAM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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