Seroatlas · Human Serome Atlas

ABHD10

Palmitoyl-protein thioesterase ABHD10, mitochondrial

Also known as: ABHDA_HUMAN, FLJ11342

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NUJ1
Gene
ABHD10
Ensembl
ENSG00000144827
Chromosome
3
Canonical length
306 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

This gene encodes a mitochondrially-localized enzyme that acts in liver cells as a hydrolase. The encoded protein removes glucuronide from mycophenolic acid acyl-glucuronide. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Canonical amino-acid sequenceUniProt

306 residues, UniProt reviewed canonical sequence.

>Q9NUJ1|ABHD10
     1  MAVARLAAVA AWVPCRSWGW AAVPFGPHRG LSVLLARIPQ RAPRWLPACR QKTSLSFLNR
    61  PDLPNLAYKK LKGKSPGIIF IPGYLSYMNG TKALAIEEFC KSLGHACIRF DYSGVGSSDG
   121  NSEESTLGKW RKDVLSIIDD LADGPQILVG SSLGGWLMLH AAIARPEKVV ALIGVATAAD
   181  TLVTKFNQLP VELKKEVEMK GVWSMPSKYS EEGVYNVQYS FIKEAEHHCL LHSPIPVNCP
   241  IRLLHGMKDD IVPWHTSMQV ADRVLSTDVD VILRKHSDHR MREKADIQLL VYTIDDLIDK
   301  LSTIVN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABHD10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
48 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 48 nTPM
  • kidney: 46 nTPM
  • liver: 32 nTPM
  • thyroid gland: 29 nTPM
  • pituitary gland: 27 nTPM
  • retina: 25 nTPM

Single-cell type

  • epididymal principal cells: 74 nCPM
  • parietal cells: 55 nCPM
  • early primary spermatocytes: 47 nCPM
  • retinal ganglion cells: 46 nCPM
  • retinal horizontal cells: 46 nCPM
  • corticotrophs: 45 nCPM

Immune cell

  • basophil: 29 nTPM
  • myeloid DC: 28 nTPM
  • memory B-cell: 26 nTPM
  • eosinophil: 25 nTPM
  • naive B-cell: 22 nTPM
  • intermediate monocyte: 22 nTPM

Brain region

  • hypothalamus: 27 nTPM
  • basal ganglia: 25 nTPM
  • white matter: 25 nTPM
  • spinal cord: 24 nTPM
  • cerebral cortex: 24 nTPM
  • cerebellum: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.06
gnomAD pLI
0
gnomAD missense Z
0.23
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ABHD10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABHD10 as an antibody target. Whether an autoantibody or antibody against ABHD10 could matter depends on whether native ABHD10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABHD10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ABHD10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ABHD10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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