Seroatlas · Human Serome Atlas

AADACL4

Arylacetamide deacetylase-like 4

Also known as: ADCL4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VUY2
Gene: AADACL4
Ensembl: ENSG00000204518
Chromosome: 1
Canonical length: 407 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable carboxylic ester hydrolase activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

407 residues, UniProt reviewed canonical sequence.

>Q5VUY2|AADACL4
     1  MAVPWLVLLL ALPIFFLGVF VWAVFEHFLT TDIPATLQHP AKLRFLHCIF LYLVTLGNIF
    61  EKLGICSMPK FIRFLHDSVR IKKDPELVVT DLRFGTIPVR LFQPKAASSR PRRGIIFYHG
   121  GATVFGSLDC YHGLCNYLAR ETESVLLMIG YRKLPDHHSP ALFQDCMNAS IHFLKALETY
   181  GVDPSRVVVC GESVGGAAVA AITQALVGRS DLPRIRAQVL IYPVVQAFCL QLPSFQQNQN
   241  VPLLSRKFMV TSLCNYLAID LSWRDAILNG TCVPPDVWRK YEKWLSPDNI PKKFKNRGYQ
   301  PWSPGPFNEA AYLEAKHMLD VENSPLIADD EVIAQLPEAF LVSCENDILR DDSLLYKKRL
   361  EDQGVRVTWY HLYDGFHGSI IFFDKKALSF PCSLKIVNAV VSYIKGI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AADACL4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 1.7 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 1.7 nTPM
vagina: 0.7 nTPM
adipose tissue: 0.6 nTPM
kidney: 0.5 nTPM
epididymis: 0.4 nTPM
cervix: 0.3 nTPM

Single-cell type

podocytes: 20 nCPM
fibro-adipogenic progenitors: 2.9 nCPM
retinal horizontal cells: 2 nCPM
decidual stromal cells: 1.8 nCPM
parietal cells: 1.8 nCPM
leydig cells: 1.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 1.5 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.68
gnomAD pLI: 0
gnomAD missense Z: -0.94
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

carboxylic ester hydrolase activity

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AADACL4 as an antibody target. Whether an autoantibody or antibody against AADACL4 could matter depends on whether native AADACL4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AADACL4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AADACL4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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