Seroatlas · Human Serome Atlas

AADACL3

Arylacetamide deacetylase-like 3

Also known as: ADCL3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VUY0
Gene: AADACL3
Ensembl: ENSG00000188984
Chromosome: 1
Canonical length: 407 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable carboxylic ester hydrolase activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

407 residues, UniProt reviewed canonical sequence.

>Q5VUY0|AADACL3
     1  MWDLALIFLA AACVFSLGVT LWVICSHFFT VHIPAAVGHP VKLRVLHCIF QLLLTWGMIF
    61  EKLRICSMPQ FFCFMQDLPP LKYDPDVVVT DFRFGTIPVK LYQPKASTCT LKPGIVYYHG
   121  GGGVMGSLKT HHGICSRLCK ESDSVVLAVG YRKLPKHKFP VPVRDCLVAT IHFLKSLDAY
   181  GVDPARVVVC GDSFGGAIAA VVCQQLVDRP DLPRIRAQIL IYAILQALDL QTPSFQQRKN
   241  IPLLTWSFIC YFFFQNLDFS SSWQEVIMKG AHLPAEVWEK YRKWLGPENI PERFKERGYQ
   301  LKPHEPMNEA AYLEVSVVLD VMCSPLIAED DIVSQLPETC IVSCEYDALR DNSLLYKKRL
   361  EDLGVPVTWH HMEDGFHGVL RTIDMSFLHF PCSMRILSAL VQFVKGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AADACL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.22
Highest tissue expression: 3 nTPM

Expression across tissuesHPA

Tissue

skin: 3 nTPM
placenta: 1.5 nTPM
breast: 0.7 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

extravillous trophoblasts: 4.3 nCPM
early spermatids: 1.1 nCPM
late primary spermatocytes: 0.7 nCPM
foveolar cells: 0.4 nCPM
mast cells: 0.3 nCPM
neutrophil progenitors: 0.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.7
gnomAD pLI: 0.01
gnomAD missense Z: -0.34
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

carboxylic ester hydrolase activity

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Hydrolase

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AADACL3 as an antibody target. Whether an autoantibody or antibody against AADACL3 could matter depends on whether native AADACL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AADACL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AADACL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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