Seroatlas · Human Serome Atlas

AADACL2

Arylacetamide deacetylase-like 2

Also known as: ADCL2_HUMAN, MGC72001

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P093
Gene: AADACL2
Ensembl: ENSG00000197953
Chromosome: 3
Canonical length: 401 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

Predicted to enable carboxylic ester hydrolase activity. Predicted to be located in extracellular region and membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

401 residues, UniProt reviewed canonical sequence.

>Q6P093|AADACL2
     1  MGLKALCLGL LCVLFVSHFY TPMPDNIEES WKIMALDAIA KTCTFTAMCF ENMRIMRYEE
    61  FISMIFRLDY TQPLSDEYIT VTDTTFVDIP VRLYLPKRKS ETRRRAVIYF HGGGFCFGSS
   121  KQRAFDFLNR WTANTLDAVV VGVDYRLAPQ HHFPAQFEDG LAAVKFFLLE KILTKYGVDP
   181  TRICIAGDSS GGNLATAVTQ QVQNDAEIKH KIKMQVLLYP GLQITDSYLP SHRENEHGIV
   241  LTRDVAIKLV SLYFTKDEAL PWAMRRNQHM PLESRHLFKF VNWSILLPEK YRKDYVYTEP
   301  ILGGLSYSLP GLTDSRALPL LANDSQLQNL PLTYILTCQH DLLRDDGLMY VTRLRNVGVQ
   361  VVHEHIEDGI HGALSFMTSP FYLRLGLRIR DMYVSWLDKN L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AADACL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.21
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

skin: 10 nTPM
adipose tissue: 0.5 nTPM
cervix: 0.5 nTPM
vagina: 0.3 nTPM
colon: 0.1 nTPM
salivary gland: 0.1 nTPM

Single-cell type

ependymal cells: 6.2 nCPM
suprabasal keratinocytes: 3 nCPM
endometrial ciliated cells: 0.9 nCPM
choroid plexus epithelial cells: 0.5 nCPM
respiratory ciliated cells: 0.5 nCPM
decidual stromal cells: 0.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.1 nTPM
medulla oblongata: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.65
gnomAD pLI: 0
gnomAD missense Z: 0.21
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

carboxylic ester hydrolase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AADACL2 as an antibody target. Whether an autoantibody or antibody against AADACL2 could matter depends on whether native AADACL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AADACL2 is annotated as secreted, so native AADACL2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label AADACL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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