Seroatlas · Human Serome Atlas

AADAC

Arylacetamide deacetylase

Also known as: AAAD_HUMAN, CES5A1, DAC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P22760
Gene: AADAC
Ensembl: ENSG00000114771
Chromosome: 3
Canonical length: 399 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

399 residues, UniProt reviewed canonical sequence.

>P22760|AADAC
     1  MGRKSLYLLI VGILIAYYIY TPLPDNVEEP WRMMWINAHL KTIQNLATFV ELLGLHHFMD
    61  SFKVVGSFDE VPPTSDENVT VTETKFNNIL VRVYVPKRKS EALRRGLFYI HGGGWCVGSA
   121  ALSGYDLLSR WTADRLDAVV VSTNYRLAPK YHFPIQFEDV YNALRWFLRK KVLAKYGVNP
   181  ERIGISGDSA GGNLAAAVTQ QLLDDPDVKI KLKIQSLIYP ALQPLDVDLP SYQENSNFLF
   241  LSKSLMVRFW SEYFTTDRSL EKAMLSRQHV PVESSHLFKF VNWSSLLPER FIKGHVYNNP
   301  NYGSSELAKK YPGFLDVRAA PLLADDNKLR GLPLTYVITC QYDLLRDDGL MYVTRLRNTG
   361  VQVTHNHVED GFHGAFSFLG LKISHRLINQ YIEWLKENL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AADAC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.22
Highest tissue expression: 884 nTPM

Expression across tissuesHPA

Tissue

liver: 884 nTPM
adrenal gland: 235 nTPM
small intestine: 228 nTPM
duodenum: 208 nTPM
stomach: 49 nTPM
pancreas: 39 nTPM

Single-cell type

hepatocytes: 848 nCPM
enterocytes: 457 nCPM
pancreatic acinar cells: 410 nCPM
adrenal cortex cells: 135 nCPM
foveolar cells: 129 nCPM
cholangiocytes: 70 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 0.4 nTPM
midbrain: 0.2 nTPM
cerebral cortex: 0.1 nTPM
hippocampal formation: 0.1 nTPM
medulla oblongata: 0.1 nTPM
pons: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.94
gnomAD pLI: 0
gnomAD missense Z: 0.36
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

endoplasmic reticulum membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AADAC as an antibody target. Whether an autoantibody or antibody against AADAC could matter depends on whether native AADAC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AADAC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AADAC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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