Williams-Beuren syndrome DDT (WSD), D-TOX E motif

Definition

This family represents the combined alpha-helical module found in diverse eukaryotic chromatin proteins PMID:22186017. Based on the Ioc3 structure, the N-terminus of this module is inferred to interact with nucleosomal linker DNA and the SLIDE domain of ISWI proteins [[cite:PMID:22186017],[cite:PMID:21525927]]. The resulting complex forms a protein ruler that measures out the spacing between two adjacent nucleosomes PMID:21525927. The acidic residue from the GxD signature at the N-terminus is a major determinant of the interaction between the ISWI and WHIM motifs. The N-terminal portion also contacts the inter-nucleosomal linker DNA. The module shows a great domain architectural diversity and is often combined with other modified histone peptide recognizing and DNA binding domains, some of which discriminate methylated DNA. The WSD module constitutes the inter-nucleosomal linker DNA binding site in the major groove of DNA PMID:22186017, and was first identified as WSD PMID:19734295, the D-TOX E motif of plant homeodomains homologous with the mutant transcription factor causing Williams-Beuren syndrome in association with the DDT-domain.

5 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (5 proteins: gene, accession, name)

• BAZ1A
• BAZ1B
• BAZ2A
• BAZ2B
• BPTF