Choline/Carnitine o-acyltransferase, domain 2
IPR042231
Definition
This superfamily represents the domain 2 of choline/carnitine o-acyltransferase. The choline/carnitine acyltransferase domain is found in a number of eukaryotic acetyltransferases. These enzymes include: Choline o-acetyltransferase [ec:2.3.1.6], an enzyme that catalyses the biosynthesis of the neurotransmitter acetylcholine PMID:3480542. Carnitine o-acetyltransferase [ec:2.3.1.7] PMID:8420957. Peroxisomal carnitine octanoyltransferase [ec:2.3.1.137], a fatty acid beta-oxidation pathway enzyme which is involved in the transport of medium-chain acyl-coenzyme A's from peroxisome to mitochondria PMID:3233218. Mitochondrial carnitine palmitoyltransferases I and II [ec:2.3.1.21] (CPT), enzymes involved in fatty acid metabolism and transport PMID:8449948. Mycoplasma pneumoniae putative acetyltransferase C09_orf600. Choline and carnitine o-acyltransferase are two evolutionary and structurally related enzymes. These are two different types of acyltransferases, a type of transferase enzymes that transfer an acetyl group. The former, choline O-acyltransferase, is involved choline biosynthesis and it is essential for the development and neuronal activities of cholinergic systems involved in many fundamental brain functions PMID:15477102. The latter, carnitine o-acyltransferase, catalyzes the reversible acylation of L-carnitine and thus plays a vital role in fatty acid beta-oxidation and maintenance of acyl coenzyme A (acyl-CoA) pools PMID:8420957. Both show a remarkably similar structure, they are monomeric proteins containing two domains (1 and 2) that interconnect to form an active site tunnel PMID:15477102. This domain is also found at the C-terminal of highly reducing polyketide synthase SdnO and related highly reducing polyketide synthases. SdnO is part of the gene cluster that mediates the biosynthesis of glycoside antibiotics sordarin and hypoxysordarin PMID:27072286.
7 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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