WHIM2 domain
IPR028941
Definition
This entry represents the WHIM2 domain found in diverse eukaryotic chromatin proteins, such as animal BAZ/WAL and BPTF proteins, plant RLT, and yeast Itc1. This domain contains the D-TOX E motif (also known as the Williams-Beuren syndrome DDT (WSD) motif) that is conserved from yeasts to animals [[cite:PMID:22186017], [cite:PMID:21525927], [cite:PMID:19734295]]. WHIM2 domain is a conserved α helical motif that along with the WHIM1 and WHIM3 motifs, and the DDT domain comprise an α helical module found in diverse eukaryotic chromatin proteins PMID:22186017. Based on the Ioc3 structure, this module is inferred to interact with nucleosomal linker DNA and the SLIDE domain of ISWI proteins [[cite:PMID:22186017], [cite:PMID:21525927]]. The resulting complex forms a protein ruler that measures out the spacing between two adjacent nucleosomes PMID:21525927. The acidic residue from the GxD signature of WHIM2 is a major determinant of the interaction between the ISWI and WHIM motifs. The N-terminal portion of the WHIM2 motif also contacts the inter-nucleosomal linker DNA. The module shows a great domain architectural diversity and is often combined with other modified histone peptide recognizing and DNA binding domains, some of which discriminate methylated DNA PMID:22186017.
5 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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