Seroatlas · Human Serome Atlas

HERVK_113

Endogenous retrovirus group K member 113 Gag polyprotein

Also known as: GA113_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P62684
Gene: HERVK_113
Canonical length: 666 aa

OverviewNCBI Gene

No narrative summary is available for HERVK_113 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

666 residues, UniProt reviewed canonical sequence.

>P62684|HERVK_113
     1  MGQTKSKIKS KYASYLSFIK ILLKRGGVKV STKNLIKLFQ IIEQFCPWFP EQGTLDLKDW
    61  KRIGKELKQA GRKGNIIPLT VWNDWAIIKA ALEPFQTEED SVSVSDAPGS CIIDCNENTR
   121  KKSQKETESL HCEYVAEPVM AQSTQNVDYN QLQEVIYPET LKLEGKVPEL VGPSESKPRG
   181  TSRLPAGQVP VTLQPQTQVK ENKTQPPVAY QYWPPAELQY RPPLESQYGY PGMPPAPQGR
   241  APYPQPPTRR LNPTAPPSRR GSELHEIIDK SRKEGDTEAW QFPVTLEPMP PGEGAQEGEP
   301  PTVEARYKSF SIKMLKDMKE GVKQYGPNSP YMRTLLDSIA HGHRLIPYDW EILAKSSLSP
   361  SQFLQFKTWW IDGVQEQVRR NRAANPPVNI DADQLLGIGQ NWSTISQQAL MQNEAIEQVR
   421  AICLRAWEKI QDPGSTCPSF NTVRQGSKEP YPDFVARLQD VAQKSIAIEK ARKVIVELMA
   481  YENPNPECQS AIKPLKGKVP AGSDVISEYV KACDGMGGAM HKAMLMAQAI TGVVLGGQVR
   541  TFGGKCYNCG QIGHLKKNCP VLNKQNITIQ ATTTGREPPD LCPRCKKGKH WASQCRSKFD
   601  KNGQPLSGNE QRGQPQAPQQ TGAFPIQPFV PHGFQGQQPP LSQVFQGISQ LPQYNNCPPP
   661  QAAVQQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HERVK_113 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HERVK_113.

Disease | ImmuneIEDB

Conditions an epitope on HERVK_113 was assayed in.

prostate cancer B cell

OntologyGO

Biological processes

viral translational frameshifting

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HERVK_113 as an antibody target. Whether an autoantibody or antibody against HERVK_113 could matter depends on whether native HERVK_113 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HERVK_113 is annotated at the cell surface, where native HERVK_113 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HERVK_113 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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