ZYG11B

Protein identityUniProt · HPA

UniProt accession

Q9C0D3

Gene

ZYG11B

Ensembl

ENSG00000162378

Chromosome

1

Canonical length

744 aa

Protein class

Predicted intracellular proteins

Subcellular location

Golgi apparatus,Intermediate filaments

OverviewNCBI Gene

Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and protein quality control for misfolded or incompletely synthesized proteins. Part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

744 residues, UniProt reviewed canonical sequence.

>Q9C0D3|ZYG11B
     1  MPEDQAGAAM EEASPYSLLD ICLNFLTTHL EKFCSARQDG TLCLQEPGVF PQEVADRLLR
    61  TMAFHGLLND GTVGIFRGNQ MRLKRACIRK AKISAVAFRK AFCHHKLVEL DATGVNADIT
   121  ITDIISGLGS NKWIQQNLQC LVLNSLTLSL EDPYERCFSR LSGLRALSIT NVLFYNEDLA
   181  EVASLPRLES LDISNTSITD ITALLACKDR LKSLTMHHLK CLKMTTTQIL DVVRELKHLN
   241  HLDISDDKQF TSDIALRLLE QKDILPNLVS LDVSGRKHVT DKAVEAFIQQ RPSMQFVGLL
   301  ATDAGYSEFL TGEGHLKVSG EANETQIAEA LKRYSERAFF VREALFHLFS LTHVMEKTKP
   361  EILKLVVTGM RNHPMNLPVQ LAASACVFNL TKQDLAAGMP VRLLADVTHL LLKAMEHFPN
   421  HQQLQKNCLL SLCSDRILQD VPFNRFEAAK LVMQWLCNHE DQNMQRMAVA IISILAAKLS
   481  TEQTAQLGTE LFIVRQLLQI VKQKTNQNSV DTTLKFTLSA LWNLTDESPT TCRHFIENQG
   541  LELFMRVLES FPTESSIQQK VLGLLNNIAE VQELHSELMW KDFIDHISSL LHSVEVEVSY
   601  FAAGIIAHLI SRGEQAWTLS RSQRNSLLDD LHSAILKWPT PECEMVAYRS FNPFFPLLGC
   661  FTTPGVQLWA VWAMQHVCSK NPSRYCSMLI EEGGLQHLYN IKDHEHTDPH VQQIAVAILD
   721  SLEKHIVRHG RPPPCKKQPQ ARLN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZYG11B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.23

Highest tissue expression

74 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZYG11B.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 84 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Craniofacial microsomia 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.25

gnomAD pLI

1

gnomAD missense Z

3.98

DepMap mean gene effect

-0.15

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• positive regulation of proteasomal ubiquitin-dependent protein catabolic process
• protein quality control for misfolded or incompletely synthesized proteins

Cellular components

• Cul2-RING ubiquitin ligase complex
• cytoplasm

Protein domainsUniProt · Pfam · InterPro

• Leucine-rich repeat
• Armadillo-like helical
• Armadillo-type fold
• Leucine-rich repeat domain superfamily
• Zyg-11-related ubiquitin ligase adapter protein
• Protein zer-1 homolog-like, C-terminal domain
• Zer-1-like, leucine-rich repeats region
• Protein zer-1 homolog-like, C-terminal domain
• Zer-1-like, Leucine-rich repeats

KeywordsUniProt

• Cytoplasm
• Host-virus interaction
• Leucine-rich repeat
• Repeat
• Ubl conjugation
• Ubl conjugation pathway

InteractionsUniProt · HPA

Protein binding partners of ZYG11B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CUL2