ZYG11A
Protein zyg-11 homolog A
Also known as: ZY11A_HUMAN, ZYG11
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6WRX3
- Gene
- ZYG11A
- Ensembl
- ENSG00000203995
- Chromosome
- 1
- Canonical length
- 759 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Predicted to be part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
759 residues, UniProt reviewed canonical sequence.
>Q6WRX3|ZYG11A
1 MVHFLHPGHT PRNIVPPDAQ KDALGCCVVQ EEASPYTLVN ICLNVLIANL EKLCSERPDG
61 TLCLPEHWSF PQEVAERFLR VMTWQGKLTD RTASIFRGNQ MKLKLVNIQK AKISTAAFIK
121 AFCRHKLIEL NATAVHADLP VPDIISGLCS NRWIQQNLQC LLLDSTSIPQ NSRLLFFSQL
181 TGLRILSVFN VCFHTEDLAN VSQLPRLESL DISNTLVTDI SALLTCKDRL KSLTMHYLKC
241 LAMTKSQILA VIRELKCLLH LDISDHRQLK SDLAFHLLQQ KDILPNVVSL DISGGNCITD
301 EAVELFIRLR PAMQFVGLLA TDAGSSDFFT TKQGLRVAGG ASMSQISEAL SRYRNRSCFV
361 KEALHRLFTE TFSMEVTMPA ILKLVAIGMR NHPLDLRVQF TASACALNLT RQGLAKGMPV
421 RLLSEVTCLL FKALKNFPHY QQLQKNCLLS LTNSRILVDV PFDRFDAAKF VMRWLCKHEN
481 PKMQTMAVSV TSILALQLSP EQTAQLEELF MAVKELLAIV KQKTTENLDD VTFLFTLKAL
541 WNLTDGSPAA CKHFIENQGL QIFIQVLETF SESAIQSKVL GLLNNIAEVR ELSSKLVTED
601 VLKHINSLLC SREMEVSYFA AGIIAHLTSD RQLWISRDFQ RRTLLQDLHA TIQNWPSSSC
661 KMTALVTYRS FKTFFPLLGN FSQPEVQLWA LWAMYHVCSK NPSKYCKMLV EEEGLQLLCD
721 IQEHSEATPK AQQIAASILD DFRMHFMNYQ RPTLCQMPFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZYG11A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.25
- Highest tissue expression
- 3.5 nTPM
Expression across tissuesHPA
Tissue
- testis: 3.5 nTPM
- kidney: 2.7 nTPM
- thyroid gland: 2.2 nTPM
- liver: 1.2 nTPM
- prostate: 0.7 nTPM
- tonsil: 0.7 nTPM
Single-cell type
- proximal tubule cells: 108 nCPM
- differentiating spermatogonia: 37 nCPM
- esophageal apical cells: 31 nCPM
- undifferentiated spermatogonia: 30 nCPM
- early primary spermatocytes: 22 nCPM
- plasma cells: 13 nCPM
Immune cell
- neutrophil: 0.5 nTPM
- basophil: 0.4 nTPM
- eosinophil: 0.1 nTPM
- memory B-cell: 0.1 nTPM
- naive B-cell: 0.1 nTPM
- naive CD8 T-cell: 0.1 nTPM
Brain region
- cerebellum: 2.3 nTPM
- choroid plexus: 1.8 nTPM
- white matter: 1.6 nTPM
- hypothalamus: 1.5 nTPM
- medulla oblongata: 1.3 nTPM
- pons: 1.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.98
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.22
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZYG11A as an antibody target. Whether an autoantibody or antibody against ZYG11A could matter depends on whether native ZYG11A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZYG11A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZYG11A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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