Seroatlas · Human Serome Atlas

ZSWIM9

Uncharacterized protein ZSWIM9

Also known as: C19orf68, LOC374920, ZSWM9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86XI8
Gene: ZSWIM9
Ensembl: ENSG00000185453
Chromosome: 19
Canonical length: 627 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to act upstream of or within hematopoietic progenitor cell differentiation. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

627 residues, UniProt reviewed canonical sequence.

>Q86XI8|ZSWIM9
     1  MERPEPPPGT AAGQEEQELR ERAFFSWAEF SRFFDAWCQQ RLALFFVKSS MHLARCRWAS
    61  APPLYTLIDV LKYSYVRLVC KDVRAPSRPA VGPPQPGCPA FIIVKLSPLR DRLVVTECQL
   121  THSHPACPLE FAYYFRPGHL LANACLPVRT TNKISKQFVA PADVRRLLSY CKGRDHGVLD
   181  ALHVLEGLFR TDPEAKVKLV FVEDQAVVET VFFLTSRTRA LLRRFPRMLL VDRLPGLQGA
   241  LDLLAVLCVD GSGRARQAAC CVARPGTPSL LRFALASLLQ SAPDVKGRVR CLTAGPEVAA
   301  QLPAVRQLLP CARVQICRAQ GLETLFSKAQ ELGGAGREDP GLWSRLCRLA GASSPAAYDE
   361  ALAELHAHGP AAFVDYFERN WEPRRDMWVR FRAFEAARDL DACALVRGHR RRLLRRLSPS
   421  RGVAQCLRDL VAMQWADAAG EAVPEGPDGG GPWLEDEPGR GAQGENERVR GLETGDWGGA
   481  PKEGSIWRGA QMEKEWARAL ETRDWGGAQF EGEKGRALQI RDWRGGRLEN QKPRGLEGGV
   541  LRGSKLEKGH LRGPEIRDWR GPQLEGEKDW GLEGYVWRGS QLEDQALRGL EGYTWRVAQL
   601  EDRRSTTDLR GTQFDYERGK GESTEDR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZSWIM9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 18 nTPM
amygdala: 15 nTPM
cerebral cortex: 13 nTPM
hippocampal formation: 13 nTPM
midbrain: 13 nTPM
hypothalamus: 13 nTPM

Single-cell type

early spermatids: 46 nCPM
late spermatids: 32 nCPM
lacrimal acinar cells: 20 nCPM
thyrotrophs: 19 nCPM
myosatellite cells: 19 nCPM
pituitary stem cells: 17 nCPM

Immune cell

memory CD8 T-cell: 0.2 nTPM
gdT-cell: 0.1 nTPM
memory B-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

medulla oblongata: 30 nTPM
amygdala: 28 nTPM
basal ganglia: 24 nTPM
midbrain: 24 nTPM
cerebral cortex: 22 nTPM
white matter: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.33
gnomAD pLI: 0.96

Protein domainsUniProt · Pfam · InterPro

Uncharacterized protein ZSWIM9
ZSWIM9, central RNaseH-like domain
DUF5575, N-terminal domain
DUF5575, C-terminal domain
DUF5575 central RNaseH like domain
DUF5575 N-terminal domain
DUF5575 C-terminal domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZSWIM9 as an antibody target. Whether an autoantibody or antibody against ZSWIM9 could matter depends on whether native ZSWIM9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZSWIM9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZSWIM9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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