Seroatlas · Human Serome Atlas

ZSWIM8

Zinc finger SWIM domain-containing protein 8

Also known as: 4832404P21Rik, KIAA0913, ZSWM8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A7E2V4
Gene: ZSWIM8
Ensembl: ENSG00000214655
Chromosome: 10
Canonical length: 1837 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Enables ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of macromolecule metabolic process; protein ubiquitination; and proteolysis involved in protein catabolic process. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1837 residues, UniProt reviewed canonical sequence.

>A7E2V4|ZSWIM8
     1  MELMFAEWED GERFSFEDSD RFEEDSLCSF ISEAESLCQN WRGWRKQSAG PNSPTGGGGG
    61  GGSGGTRMRD GLVIPLVELS AKQVAFHIPF EVVEKVYPPV PEQLQLRIAF WSFPENEEDI
   121  RLYSCLANGS ADEFQRGDQL FRMRAVKDPL QIGFHLSATV VPPQMVPPKG AYNVAVMFDR
   181  CRVTSCSCTC GAGAKWCTHV VALCLFRIHN ASAVCLRAPV SESLSRLQRD QLQKFAQYLI
   241  SELPQQILPT AQRLLDELLS SQSTAINTVC GAPDPTAGPS ASDQSTWYLD ESTLTDNIKK
   301  TLHKFCGPSP VVFSDVNSMY LSSTEPPAAA EWACLLRPLR GREPEGVWNL LSIVREMFKR
   361  RDSNAAPLLE ILTDQCLTYE QITGWWYSVR TSASHSSASG HTGRSNGQSE VAAHACASMC
   421  DEMVTLWRLA VLDPALSPQR RRELCTQLRQ WQLKVIENVK RGQHKKTLER LFPGFRPAVE
   481  ACYFNWEEAY PLPGVTYSGT DRKLALCWAR ALPSRPGASR SGGLEESRDR PRPLPTEPAV
   541  RPKEPGTKRK GLGEGVPSSQ RGPRRLSAEG GDKALHKMGP GGGKAKALGG AGSGSKGSAG
   601  GGSKRRLSSE DSSLEPDLAE MSLDDSSLAL GAEASTFGGF PESPPPCPLH GGSRGPSTFL
   661  PEPPDTYEED GGVYFSEGPE PPTASVGPPG LLPGDVCTQD DLPSTDESGN GLPKTKEAAP
   721  AVGEEDDDYQ AYYLNAQDGA GGEEEKAEGG AGEEHDLFAG LKPLEQESRM EVLFACAEAL
   781  HAHGYSSEAS RLTVELAQDL LANPPDLKVE PPPAKGKKNK VSTSRQTWVA TNTLSKAAFL
   841  LTVLSERPEH HNLAFRVGMF ALELQRPPAS TKALEVKLAY QESEVAALLK KIPLGPSEMS
   901  TMRCRAEELR EGTLCDYRPV LPLMLASFIF DVLCAPGSRP PSRNWNSETP GDEELGFEAA
   961  VAALGMKTTV SEAEHPLLCE GTRREKGDLA LALMITYKDD QAKLKKILDK LLDRESQTHK
  1021  PQTLSSFYSS SRPTTASQRS PSKHGGPSAP GALQPLTSGS AGPAQPGSVA GAGPGPTEGF
  1081  TEKNVPESSP HSPCEGLPSE AALTPRPEGK VPSRLALGSR GGYNGRGWGS PGRPKKKHTG
  1141  MASIDSSAPE TTSDSSPTLS RRPLRGGWAP TSWGRGQDSD SISSSSSDSL GSSSSSGSRR
  1201  ASASGGARAK TVEVGRYKGR RPESHAPHVP NQPSEAAAHF YFELAKTVLI KAGGNSSTSI
  1261  FTHPSSSGGH QGPHRNLHLC AFEIGLYALG LHNFVSPNWL SRTYSSHVSW ITGQAMEIGS
  1321  AALTILVECW DGHLTPPEVA SLADRASRAR DSNMVRAAAE LALSCLPHAH ALNPNEIQRA
  1381  LVQCKEQDNL MLEKACMAVE EAAKGGGVYP EVLFEVAHQW FWLYEQTAGG SSTAREGATS
  1441  CSASGIRAGG EAGRGMPEGR GGPGTEPVTV AAAAVTAAAT VVPVISVGSS LYPGPGLGHG
  1501  HSPGLHPYTA LQPHLPCSPQ YLTHPAHPAH PMPHMPRPAV FPVPSSAYPQ GVHPAFLGAQ
  1561  YPYSVTPPSL AATAVSFPVP SMAPITVHPY HTEPGLPLPT SVACELWGQG TVSSVHPAST
  1621  FPAIQGASLP ALTTQPSPLV SGGFPPPEEE THSQPVNPHS LHHLHAAYRV GMLALEMLGR
  1681  RAHNDHPNNF SRSPPYTDDV KWLLGLAAKL GVNYVHQFCV GAAKGVLSPF VLQEIVMETL
  1741  QRLSPAHAHN HLRAPAFHQL VQRCQQAYMQ YIHHRLIHLT PADYDDFVNA IRSARSAFCL
  1801  TPMGMMQFND ILQNLKRSKQ TKELWQRVSL EMATFSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZSWIM8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 143 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 143 nTPM
liver: 143 nTPM
spleen: 107 nTPM
esophagus: 104 nTPM
adrenal gland: 97 nTPM
testis: 95 nTPM

Single-cell type

esophageal apical cells: 128 nCPM
adrenal cortex cells: 101 nCPM
neutrophils: 91 nCPM
adrenal medulla cells: 75 nCPM
retinal horizontal cells: 74 nCPM
astrocytes: 69 nCPM

Immune cell

neutrophil: 5 nTPM
plasmacytoid DC: 3.8 nTPM
gdT-cell: 3 nTPM
non-classical monocyte: 2.6 nTPM
basophil: 2.4 nTPM
classical monocyte: 2.2 nTPM

Brain region

white matter: 44 nTPM
cerebral cortex: 44 nTPM
choroid plexus: 42 nTPM
medulla oblongata: 42 nTPM
thalamus: 41 nTPM
hippocampal formation: 40 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZSWIM8.

Disease | ImmuneIEDB

Conditions an epitope on ZSWIM8 was assayed in.

human immunodeficiency virus infectious disease T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.13
gnomAD pLI: 1
gnomAD missense Z: 5.14
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger, SWIM-type
ZSWIM4-8, C-terminal
ZSWIM4-8, C-terminal
ZSWIM8, TPR repeats
ZSWIM8, TPR repeats

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZSWIM8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DAB1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZSWIM8 as an antibody target. Whether an autoantibody or antibody against ZSWIM8 could matter depends on whether native ZSWIM8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZSWIM8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZSWIM8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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