Seroatlas · Human Serome Atlas

ZSWIM5

Zinc finger SWIM domain-containing protein 5

Also known as: KIAA1511, ZSWM5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P217
Gene: ZSWIM5
Ensembl: ENSG00000162415
Chromosome: 1
Canonical length: 1185 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1185 residues, UniProt reviewed canonical sequence.

>Q9P217|ZSWIM5
     1  MADGGEREEL LSPSPVSPAK RQCSWPSPQA HHPRGSPGAA GGGAGGVGSS CLVLGARPHL
    61  QPDSLLDCAA KTVAEKWAYE RVEERFERIP EPVQRRIVYW SFPRNEREIC MYSSFQYRGG
   121  PGAGAAGGAA GASPAEEGPQ PPPGAAAPAG SAPGGVAAGA SPGLGAGAGA AGCGGEGLPF
   181  RRGIRLLDSG SVENVLQVGF HLSGTVTELA TASEPAVTYK VAISFDRCKI TSVTCGCGNK
   241  DIFYCAHVVA LSLYRIRKPD QVKLRLPISE TLFQMNRDQL QKFIQYLITA HHTEVLPTAQ
   301  KLADEILSSN SEINQVNGAP DPTAGASIDD ENCWHLDEEQ VKEQVKLFLS QGGYCGSGKQ
   361  LNSMFAKVRE MLRMRDSNGA RMLTLITEQF VADPRLTLWR QQGTNMTDKC RQLWDELGAL
   421  WVCIILNPHC KLEEKSCWLQ QLQKWSDLDV CPLEDGNYGH ELPNITNALP QSAIHSPDSL
   481  SRPRRTVFTR AIEGRELHWQ DSHLQRIISS DVYTAPACQR ESERLLFNSQ GQPLWLEHVP
   541  TACARVDALR SHGYPKEALR LTVAIINTLR LQQQRQLEIY KHQKKELLQR GTTTITNLEG
   601  WVGHPLDPID CLFLTLTEAC RLNDDGYLEM SDMNESRPPV YQHVPVAAGS PNSSESYLSL
   661  ALEVALMGLG QQRLMPEGLY AQDKVCRNEE QLLSQLQELQ LDDELVQTLQ KQCILLLEGG
   721  PFSGLGEVIH RESVPMHTFA KYLFSALLPH DPDLSYKLAL RAMRLPVLEN SASAGDTSHP
   781  HHMVSVVPSR YPRWFTLGHL ESQQCELAST MLTAAKGDTL RLRTILEAIQ KHIHSSSLIF
   841  KLAQDAFKIA TPTDSSTDST LLNVALELGL QVMRMTLSTL NWRRREMVRW LVTCATEVGV
   901  RALVSILQSW YTLFTPTEAT SIVAATAVSH TTILRLSLDY PQREELASCA RTLALQCAMK
   961  DPQSCALSAL TLCEKDHIAF EAAYQIAIDA AAGGMTHSQL FTIARYMELR GYPLRAFKLA
  1021  SLAMSHLNLA YNQDTHPAIN DVLWACALSH SLGKNELAAL IPLVVKSVHC ATVLSDILRR
  1081  CTVTAPGLAG IPGRRSSGKL MSTDKAPLRQ LLDATINAYI NTTHSRLTHI SPRHYGEFIE
  1141  FLSKARETFL LPQDGHLQFA QFIDNLKQIY KGKKKLMLLV RERFG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZSWIM5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 11 nTPM
retina: 7.9 nTPM
ovary: 7.3 nTPM
cerebellum: 7.2 nTPM
small intestine: 6.4 nTPM
parathyroid gland: 5.6 nTPM

Single-cell type

adrenal cortex cells: 529 nCPM
lactotrophs: 332 nCPM
bergmann glia: 323 nCPM
cone photoreceptor cells: 306 nCPM
podocytes: 254 nCPM
oligodendrocyte progenitor cells: 221 nCPM

Immune cell

naive CD4 T-cell: 0.3 nTPM
gdT-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
NK-cell: 0.1 nTPM
T-reg: 0.1 nTPM
basophil: 0 nTPM

Brain region

cerebellum: 13 nTPM
hypothalamus: 9 nTPM
basal ganglia: 8.7 nTPM
midbrain: 8.6 nTPM
medulla oblongata: 8.1 nTPM
cerebral cortex: 7.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.4
gnomAD pLI: 0.04
gnomAD missense Z: 2.32
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

zinc ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZSWIM5 as an antibody target. Whether an autoantibody or antibody against ZSWIM5 could matter depends on whether native ZSWIM5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZSWIM5 is annotated as secreted, so native ZSWIM5 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ZSWIM5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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