Seroatlas · Human Serome Atlas

ZSWIM4

Zinc finger SWIM domain-containing protein 4

Also known as: FLJ12221, ZSWM4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H7M6
Gene: ZSWIM4
Ensembl: ENSG00000132003
Chromosome: 19
Canonical length: 989 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Predicted to be part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

989 residues, UniProt reviewed canonical sequence.

>Q9H7M6|ZSWIM4
     1  MEPPAAKRSR GCPAGPEERD AGAGAARGRG RPEALLDLSA KRVAESWAFE QVEERFSRVP
    61  EPVQKRIVFW SFPRSEREIC MYSSLGYPPP EGEHDARVPF TRGLHLLQSG AVDRVLQVGF
   121  HLSGNIREPG SPGEPERLYH VSISFDRCKI TSVSCGCDNR DLFYCAHVVA LSLYRIRHAH
   181  QVELRLPISE TLSQMNRDQL QKFVQYLISA HHTEVLPTAQ RLADEILLLG SEINLVNGAP
   241  DPTAGAGIED ANCWHLDEEQ IQEQVKQLLS NGGYYGASQQ LRSMFSKVRE MLRMRDSNGA
   301  RMLILMTEQF LQDTRLALWR QQGAGMTDKC RQLWDELGAL WVCVVLSPHC KPEERAGWLQ
   361  LLSRWDKLDV CPLEEGNYSF DGPSLQPTMA PAPELLQKGS TCITNTEGWV GHPLDPIGCL
   421  CRALLEACRL EEETLTLYPD SGPEKRKVAY QHVPVPGSPG ESYLVLALEV ALLGLGQQRA
   481  LPEGLYAQDK VVRNEEQLLA LLEEVELDER LVQVLRKQAG LLLEGGPFSG FGEVLFRESV
   541  PMHTCARYLF TALLPHDPDL AYRLALRAMR LPILETAFPA GEPHPSPLDS IMSNRFPRWF
   601  ILGHLETRQC ELASTMLTAA KGDPKWLHTV LGSIQQNIHS PALLFKLAQD ACKTATPVSA
   661  PPDTTLLGIA LELGLQVMRM TLNVMTWRRR EMVRWLVSCA TEIGPQALMN IMQNWYSLFT
   721  PVEAATIVAV TGTTHATLLR LQLDTSRREE LWACARTLAL QCAMKDPQNC ALPALTLCEK
   781  NHSAFEAAYQ IVLDAAAGGL GHAHLFTVAR YMEHRGLPLR AYKLATLALA QLSIAFNQDS
   841  HPAVNDVLWA CSLSHSLGRH ELSAIVPLII RSIHCAPMLS DILRRWTLSA PGLGPLGARR
   901  AAKPLGADRA PLCQLLDAAV TAYITTSHSR LTHISPRHYG DFIEFLGKAR ETFLLAPDGH
   961  LQFSQFLENL KQTYKGKKKL MLLVRERFG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZSWIM4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

esophagus: 11 nTPM
salivary gland: 10 nTPM
skin: 4.7 nTPM
vagina: 4.7 nTPM
cervix: 3.5 nTPM
adrenal gland: 3.4 nTPM

Single-cell type

papillary tip epithelial cells: 32 nCPM
renal collecting duct principal cells: 21 nCPM
loop of henle epithelial cells: 20 nCPM
renal connecting tubule cells: 20 nCPM
proximal tubule cells: 18 nCPM
distal convoluted tubule cells: 14 nCPM

Immune cell

neutrophil: 0.2 nTPM
MAIT T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 6.8 nTPM
pons: 6.4 nTPM
thalamus: 6.4 nTPM
choroid plexus: 6.2 nTPM
medulla oblongata: 6.1 nTPM
midbrain: 5.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.57
gnomAD pLI: 0
gnomAD missense Z: 2.29
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

zinc ion binding

Cellular components

Cul2-RING ubiquitin ligase complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZSWIM4 as an antibody target. Whether an autoantibody or antibody against ZSWIM4 could matter depends on whether native ZSWIM4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZSWIM4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZSWIM4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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