Seroatlas · Human Serome Atlas

ZSWIM3

Zinc finger SWIM domain-containing protein 3

Also known as: C20orf164, dJ337O18.7, PPP1R174, ZSWM3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96MP5
Gene
ZSWIM3
Ensembl
ENSG00000132801
Chromosome
20
Canonical length
696 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli fibrillar center,Vesicles,Cytosol

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

696 residues, UniProt reviewed canonical sequence.

>Q96MP5|ZSWIM3
     1  MELGSCFKTY EDFKECFSAY KRENRCSFIL RDCVSVRFHN LNHGTSIRED ILYVQVKFVC
    61  IRTQSNRKRT READMCPAYL LLRYNERLDR LFISELNTQH IHGDSKVASP GGDTTGKSQK
   121  TMCLQRLQPV QPTTKKDLDT AEKSLVEPSF CLDKVQVSSK PEQEGITPSD LAKIAKVMKN
   181  FLKVDEGSMA SFSVGDSQHL DRLSFQSSKM TDLFIRFPEN LLLHRVENTQ GHILYAFLVE
   241  NKERESRVVH FAVLKAETVT SVAKMLSIFT EFNSDWPKVK VVFVDPSFHY RAILQEIFPA
   301  ARILLSIYHT TRLLEKKLHR SSANPSFKRL MKEALREAVF VTSEASLKNL CQMSQAVLDE
   361  DLFNFLQAHW FTCELLWYMH VRKGLLACNT YMDSLDIVTS KVSSLFREQQ SLLDCILCFV
   421  DYIDFFNTKG LKNLPTPPPK LKRARPASMP LKSKKAFGIC GESLTSLPAE ETKPDAQQVQ
   481  VQQQSQVPPS QVGMLDTLHQ SGSELAYKLC HNEWEVVQNS THLVDMAGSS VDVQLLEDSH
   541  QVSKDGCSCS CSFQQWYHLP CRHILALLHT SQQPVGEAMV CRRWQKKYQY LLGPNGELQD
   601  RGMVPNTGQP EKQGRNDMIQ DLSRELANLL MQTEGPELEE RYSTLRKIVD IWAGPSQPSE
   661  LFQQPGDFKD VGRLPFLWGK QEEGEGFPPA TAVMHY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZSWIM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
3.6 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 3.6 nTPM
  • thymus: 3.3 nTPM
  • lymph node: 3.2 nTPM
  • retina: 3.1 nTPM
  • testis: 3.1 nTPM
  • spleen: 3 nTPM

Single-cell type

  • cone photoreceptor cells: 27 nCPM
  • enterocytes: 24 nCPM
  • myonuclei: 24 nCPM
  • retinal ganglion cells: 23 nCPM
  • tuft cells: 23 nCPM
  • colonocytes: 22 nCPM

Immune cell

  • non-classical monocyte: 4.8 nTPM
  • MAIT T-cell: 2.8 nTPM
  • T-reg: 2.4 nTPM
  • memory B-cell: 2.1 nTPM
  • memory CD8 T-cell: 2 nTPM
  • naive CD8 T-cell: 2 nTPM

Brain region

  • cerebellum: 5.5 nTPM
  • hypothalamus: 4.5 nTPM
  • basal ganglia: 4.4 nTPM
  • cerebral cortex: 4.4 nTPM
  • pons: 4.2 nTPM
  • midbrain: 4.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.76
gnomAD pLI
0
gnomAD missense Z
1.64
DepMap mean gene effect
0.27
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZSWIM3 as an antibody target. Whether an autoantibody or antibody against ZSWIM3 could matter depends on whether native ZSWIM3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZSWIM3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZSWIM3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZSWIM3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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