Seroatlas · Human Serome Atlas

ZSWIM1

Zinc finger SWIM domain-containing protein 1

Also known as: C20orf162, dJ337O18.5, ZSWM1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BR11
Gene: ZSWIM1
Ensembl: ENSG00000168612
Chromosome: 20
Canonical length: 485 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

485 residues, UniProt reviewed canonical sequence.

>Q9BR11|ZSWIM1
     1  MLERLKAPWS AALQRKYFDL GIWTAPISPM ALTMLNGLLI KDSSPPMLLH QVNKTAQLDT
    61  FNYQSCFMQS VFDHFPEILF IHRTYNPRGK VLYTFLVDGP RVQLEGHLAR AVYFAIPAKE
   121  DTEGLAQMFQ VFKKFNPAWE RVCTILVDPH FLPLPILAME FPTAEVLLSA FHICKFLQAK
   181  FYQLSLERPV ERLLLTSLQS TMCSATAGNL RKLYTLLSNC IPPAKLPELH SHWLLNDRIW
   241  LAHRWRSRAE SSHYFQSLEV TTHILSQFFG TTPSEKQGMA SLFRYMQQNS ADKANFNQGL
   301  CAQNNHAPSD TIPESPKLEQ LVESHIQHSL NAICTGPAAQ LCLGELAVVQ KSTHLIGSGS
   361  EKMNIQILED THKVQPQPPA SCSCYFNQAF HLPCRHILAM LSARRQVLQP DMLPAQWTAG
   421  CATSLDSILG SKWSETLDKH LAVTHLTEEV GQLLQHCTKE EFERRYSTLR ELADSWIGPY
   481  EQVQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZSWIM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 15 nTPM
cerebellum: 8.5 nTPM
retina: 7.5 nTPM
liver: 7.2 nTPM
adrenal gland: 7.1 nTPM
ovary: 6.8 nTPM

Single-cell type

cardiomyocytes: 17 nCPM
megakaryocytes: 12 nCPM
adrenal medulla cells: 11 nCPM
epicardial cells: 9.1 nCPM
retinal pigment epithelial cells: 8.5 nCPM
paneth cells: 7.7 nCPM

Immune cell

eosinophil: 3.6 nTPM
memory B-cell: 2.4 nTPM
basophil: 2.3 nTPM
naive CD4 T-cell: 2.3 nTPM
naive B-cell: 2.2 nTPM
plasmacytoid DC: 2.2 nTPM

Brain region

cerebellum: 15 nTPM
cerebral cortex: 12 nTPM
white matter: 12 nTPM
midbrain: 12 nTPM
thalamus: 12 nTPM
choroid plexus: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.65
gnomAD pLI: 0
gnomAD missense Z: 1.22
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

zinc ion binding

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZSWIM1 as an antibody target. Whether an autoantibody or antibody against ZSWIM1 could matter depends on whether native ZSWIM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZSWIM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZSWIM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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