ZPBP
Zona pellucida-binding protein 1
Also known as: SP38, ZPBP1, ZPBP1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BS86
- Gene
- ZPBP
- Ensembl
- ENSG00000042813
- Chromosome
- 7
- Canonical length
- 351 aa
- Protein class
- Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted secreted proteins
- Secretome location
- Secreted in male reproductive system
OverviewNCBI Gene
ZPBP is one of several proteins that are thought to participate in secondary binding between acrosome-reacted sperm and the egg-specific extracellular matrix, the zona pellucida (McLeskey et al., 1998 [PubMed 9378618]).[supplied by OMIM, Aug 2008]
Canonical amino-acid sequenceUniProt
351 residues, UniProt reviewed canonical sequence.
>Q9BS86|ZPBP
1 MEAFALGPAR RGRRRTRAAG SLLSRAAILL FISAFLVRVP SSVGHLVRLP RAFRLTKDSV
61 KIVGSTSFPV KAYVMLHQKS PHVLCVTQQL RNAELIDPSF QWYGPKGKVV SVENRTAQIT
121 STGSLVFQNF EESMSGIYTC FLEYKPTVEE IVKRLQLKYA IYAYREPHYY YQFTARYHAA
181 PCNSIYNISF EKKLLQILSK LLLDLSCEIS LLKSECHRVK MQRAGLQNEL FFAFSVSSLD
241 TEKGPKRCTD HNCEPYKRLF KAKNLIERFF NQQVEILGRR AEQLPQIYYI EGTLQMVWIN
301 RCFPGYGMNV QQHPKCPECC VICSPGSYNP RDGIHCLQCN SSLVYGAKTC LLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZPBP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.37
- Highest tissue expression
- 134 nTPM
Expression across tissuesHPA
Tissue
- testis: 134 nTPM
- retina: 4.2 nTPM
- epididymis: 0.7 nTPM
- fallopian tube: 0.3 nTPM
- thyroid gland: 0.3 nTPM
- kidney: 0.2 nTPM
Single-cell type
- late primary spermatocytes: 1,734 nCPM
- cardiomyocytes: 979 nCPM
- early spermatids: 927 nCPM
- retinal bipolar cells: 795 nCPM
- rod photoreceptor cells: 656 nCPM
- early primary spermatocytes: 296 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 0.4 nTPM
- amygdala: 0.3 nTPM
- cerebral cortex: 0.3 nTPM
- hypothalamus: 0.3 nTPM
- midbrain: 0.3 nTPM
- thalamus: 0.3 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about ZPBP.
Disease | AllUniProt
Conditions ZPBP is implicated in, by any mechanism.
- Spermatogenic failure 66 (SPGF66) MIM:619799
Disease | GeneticClinVar
1 pathogenic / likely-pathogenic of 62 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
- Spermatogenic failure 66
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.8
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.89
- DepMap mean gene effect
- 0.22
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Immunoglobulin-like domain
- Zona-pellucida-binding
- Immunoglobulin-like fold
- Immunoglobulin-like domain superfamily
- Zona-pellucida-binding protein 1/2, C-terminal domain
- Zona-pellucida-binding protein 1/2, N-terminal domain
- Zona-pellucida-binding protein (Sp38) N-terminal Ig domain
- Zona-pellucida-binding protein (Sp38) C-terminal EGF-like domain
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ZPBP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZPBP as an antibody target. Whether an autoantibody or antibody against ZPBP could matter depends on whether native ZPBP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZPBP is annotated as secreted, so native ZPBP circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label ZPBP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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