Seroatlas · Human Serome Atlas

ZNF99

Zinc finger protein 99

Also known as: C19orf9, MGC24986, ZNF99_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MXY4
Gene: ZNF99
Ensembl: ENSG00000213973
Chromosome: 19
Canonical length: 864 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

864 residues, UniProt reviewed canonical sequence.

>A8MXY4|ZNF99
     1  MGSLTFWDVT IEFALEEWQC LDMAQQNLYR NVMLENYRNL VFLGIAVSKL DLITCLKQGK
    61  EPWNMKRHEM VTKPPVISSH FTQDFWPDQS IKDSFQEIIL RTYARCGHKN LRLRKDCESV
   121  NEGKMHEEAY NKLNQCWTTT QGKIFQCNKY VKVFHKYSNS NRYKIRHTKK KTFKCMKCSK
   181  SFFMLSHLIQ HKRIHTRENI YKCEERGKAF KWFSTLIKHK IIHTEDKPYK YKKCGKAFNI
   241  SSMFTKCKII HTGKKPCKCE ECGKVFNNSS TLMKHKIIHT GKKPYKCEEC GKAFKQSSHL
   301  TRHKAIHTGE KPYKCEECGK AFNHFSALRK HQIIHTGKKP YKCEECGKAF SQSSTLRKHE
   361  IIHTEEKPYK YEECGKAFSN LSALRKHEII HTGQKPYKCE ECGKAFKWSS KLTVHKVIHT
   421  AEKPCKCEEC GKAFKRFSAL RKHKIIHTGK QPYKCEECSK AFSNFSALRK HEIIHTGEKP
   481  YKCEECGKAF KWSSKLTVHK VIHMEEKPCK CEECGKAFKH FSALRKHKII HTGKKPYKCE
   541  ECGKAFNNSS TLMKHKIIHT GKKPYKCEEC GKAFKQSSHL TRHKAIHTGE KPYKCEECGK
   601  AFNHFSALRK HQIIHTGKKP YKCEECGKAF SQSSTLRKHE IIHTGEKPYK CEECGKAFKW
   661  SSHLTRHKVI HTEEKPYKCE ECGKAFNHFS ALRKHKIIHT GKKPYKCEEC GKAFSQSSTL
   721  RKHEIIHTGE KPYKCEECGK AFKWSSKLTV HKVIHTAEKP CKCEECGKAF KHFSALRKHK
   781  IIHTGKKPYK CEECGKAFNN SSTLRKHEII HTGEKSYKCE ECGKAFQWSS KLTLHKVIHM
   841  ERNPANVKNV AKLLNISQPL ENMR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF99 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 1.5 nTPM

Expression across tissuesHPA

Tissue

testis: 1.5 nTPM
cerebral cortex: 0.2 nTPM
epididymis: 0.2 nTPM
bone marrow: 0.1 nTPM
breast: 0.1 nTPM
cervix: 0.1 nTPM

Single-cell type

early primary spermatocytes: 48 nCPM
epididymal clear cells: 12 nCPM
distal convoluted tubule cells: 12 nCPM
renal collecting duct intercalated cells: 12 nCPM
late primary spermatocytes: 11 nCPM
renal connecting tubule cells: 9.4 nCPM

Immune cell

neutrophil: 0.5 nTPM
basophil: 0.3 nTPM
plasmacytoid DC: 0.2 nTPM
intermediate monocyte: 0.1 nTPM
memory B-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM

Brain region

white matter: 1.9 nTPM
cerebral cortex: 1.7 nTPM
hippocampal formation: 1.7 nTPM
amygdala: 1.6 nTPM
hypothalamus: 1.6 nTPM
medulla oblongata: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.38
gnomAD pLI: 0.02
gnomAD missense Z: -2.52
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF99 as an antibody target. Whether an autoantibody or antibody against ZNF99 could matter depends on whether native ZNF99 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF99 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF99 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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