ZNF98
Zinc finger protein 98
Also known as: F7175, ZNF739, ZNF98_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A6NK75
- Gene
- ZNF98
- Ensembl
- ENSG00000197360
- Chromosome
- 19
- Canonical length
- 572 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
572 residues, UniProt reviewed canonical sequence.
>A6NK75|ZNF98
1 MPGPLGSLEM GVLTFRDVAL EFSLEEWQCL DTAQQNLYRN VMLENYRNLV FVGIAASKPD
61 LITCLEQGKE PWNVKRHEMV TEPPVVYSYF AQDLWPKQGK KNYFQKVILR TYKKCGRENL
121 QLRKYCKSMD ECKVHKECYN GLNQCLTTTQ NKIFQYDKYV KVFHKFSNSN RHKIGHTGKK
181 SFKCKECEKS FCMLSHLAQH KRIHSGEKPY KCKECGKAYN EASNLSTHKR IHTGKKPYKC
241 EECGKAFNRL SHLTTHKIIH TGKKPYKCEE CGKAFNQSAN LTTHKRIHTG EKPYKCEECG
301 RAFSQSSTLT AHKIIHAGEK PYKCEECGKA FSQSSTLTTH KIIHTGEKFY KCEECGKAFS
361 RLSHLTTHKR IHSGEKPYKC EECGKAFKQS STLTTHKRIH AGEKFYKCEV CSKAFSRFSH
421 LTTHKRIHTG EKPYKCEECG KAFNLSSQLT THKIIHTGEK PYKCEECGKA FNQSSTLSKH
481 KVIHTGEKPY KCEECGKAFN QSSHLTTHKM IHTGEKPYKC EECGKAFNNS SILNRHKMIH
541 TGEKLYKPES CNNACDNIAK ISKYKRNCAG EKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF98 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.43
- Highest tissue expression
- 35 nTPM
Expression across tissuesHPA
Tissue
- pancreas: 35 nTPM
- ovary: 8.8 nTPM
- testis: 7 nTPM
- epididymis: 5.3 nTPM
- basal ganglia: 4.9 nTPM
- thyroid gland: 4.4 nTPM
Single-cell type
- astrocytes: 406 nCPM
- pancreatic acinar cells: 212 nCPM
- granulosa cells: 198 nCPM
- renal connecting tubule cells: 150 nCPM
- early spermatids: 118 nCPM
- distal convoluted tubule cells: 92 nCPM
Immune cell
- plasmacytoid DC: 0.3 nTPM
- memory B-cell: 0.2 nTPM
- naive B-cell: 0.2 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- cerebral cortex: 25 nTPM
- white matter: 16 nTPM
- basal ganglia: 15 nTPM
- hypothalamus: 12 nTPM
- midbrain: 7.8 nTPM
- hippocampal formation: 7.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.64
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.57
- DepMap mean gene effect
- -0.25
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF98 as an antibody target. Whether an autoantibody or antibody against ZNF98 could matter depends on whether native ZNF98 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF98 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF98 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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