Seroatlas · Human Serome Atlas

ZNF93

Zinc finger protein 93

Also known as: FLJ12488, HPF34, TF34, ZNF505, ZNF93_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P35789
Gene: ZNF93
Ensembl: ENSG00000184635
Chromosome: 19
Canonical length: 620 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in transposable element silencing. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

620 residues, UniProt reviewed canonical sequence.

>P35789|ZNF93
     1  MGPLQFRDVA IEFSLEEWHC LDTAQRNLYR NVMLENYSNL VFLGIVVSKP DLIAHLEQGK
    61  KPLTMKRHEM VANPSVICSH FAQDLWPEQN IKDSFQKVIL RRYEKRGHGN LQLIKRCESV
   121  DECKVHTGGY NGLNQCSTTT QSKVFQCDKY GKVFHKFSNS NRHNIRHTEK KPFKCIECGK
   181  AFNQFSTLIT HKKIHTGEKP YICEECGKAF KYSSALNTHK RIHTGEKPYK CDKCDKAFIA
   241  SSTLSKHEII HTGKKPYKCE ECGKAFNQSS TLTKHKKIHT GEKPYKCEEC GKAFNQSSTL
   301  TKHKKIHTGE KPYVCEECGK AFKYSRILTT HKRIHTGEKP YKCNKCGKAF IASSTLSRHE
   361  FIHMGKKHYK CEECGKAFIW SSVLTRHKRV HTGEKPYKCE ECGKAFKYSS TLSSHKRSHT
   421  GEKPYKCEEC GKAFVASSTL SKHEIIHTGK KPYKCEECGK AFNQSSSLTK HKKIHTGEKP
   481  YKCEECGKAF NQSSSLTKHK KIHTGEKPYK CEECGKAFNQ SSTLIKHKKI HTREKPYKCE
   541  ECGKAFHLST HLTTHKILHT GEKPYRCREC GKAFNHSATL SSHKKIHSGE KPYECDKCGK
   601  AFISPSSLSR HEIIHTGEKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF93 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 6.5 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 6.5 nTPM
ovary: 6.2 nTPM
thymus: 5.6 nTPM
lymph node: 4.7 nTPM
tonsil: 4.6 nTPM
endometrium: 4.2 nTPM

Single-cell type

oocytes: 124 nCPM
extravillous trophoblasts: 36 nCPM
thymocytes: 25 nCPM
tuft cells: 23 nCPM
migrating cytotrophoblasts: 23 nCPM
megakaryocyte progenitors: 22 nCPM

Immune cell

eosinophil: 7.2 nTPM
naive B-cell: 6 nTPM
neutrophil: 5.2 nTPM
memory B-cell: 4.1 nTPM
NK-cell: 4.1 nTPM
T-reg: 4 nTPM

Brain region

cerebellum: 15 nTPM
basal ganglia: 12 nTPM
white matter: 11 nTPM
cerebral cortex: 10 nTPM
thalamus: 9.9 nTPM
medulla oblongata: 9.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.81
gnomAD pLI: 0
gnomAD missense Z: -0.04
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF93 as an antibody target. Whether an autoantibody or antibody against ZNF93 could matter depends on whether native ZNF93 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF93 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF93 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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