Seroatlas · Human Serome Atlas

ZNF92

Zinc finger protein 92

Also known as: HPF12, TF12, ZNF92_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q03936
Gene: ZNF92
Ensembl: ENSG00000146757
Chromosome: 7
Canonical length: 586 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

586 residues, UniProt reviewed canonical sequence.

>Q03936|ZNF92
     1  MGPLTFRDVK IEFSLEEWQC LDTAQRNLYR DVMLENYRNL VFLGIAVSKP DLITWLEQGK
    61  EPWNLKRHEM VDKTPVMCSH FAQDVWPEHS IKDSFQKVIL RTYGKYGHEN LQLRKDHKSV
   121  DACKVYKGGY NGLNQCLTTT DSKIFQCDKY VKVFHKFPNV NRNKIRHTGK KPFKCKNRGK
   181  SFCMLSQLTQ HKKIHTREYS YKCEECGKAF NWSSTLTKHK IIHTGEKPYK CEECGKAFNR
   241  SSNLTKHKII HTGEKPYKCE ECGKAFNRSS TLTKHKRIHT EEKPYKCEEC GKAFNQFSIL
   301  NKHKRIHMED KPYKCEECGK AFRVFSILKK HKIIHTGEKP YKCEECGKAF NQFSNLTKHK
   361  IIHTGEKPYK CDECGKAFNQ SSTLTKHKRI HTGEKPYKCE ECGKAFKQSS TLTEHKIIHT
   421  GEKPYKCEKC GKAFSWSSAF TKHKRNHMED KPYKCEECGK AFSVFSTLTK HKIIHTREKP
   481  YKCEECGKAF NQSSIFTKHK IIHTEGKSYK CEKCGNAFNQ SSNLTARKII YTGEKPYKYE
   541  ECDKAFNKFS TLITHQIIYT GEKPCKHECG RAFNKSSNYT KEKLQT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF92 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 16 nTPM
lymph node: 10 nTPM
breast: 9.7 nTPM
thymus: 9.5 nTPM
tonsil: 9 nTPM
spleen: 6.3 nTPM

Single-cell type

esophageal apical cells: 93 nCPM
b-cells: 66 nCPM
innate lymphoid cells: 59 nCPM
thymocytes: 52 nCPM
nk-cells: 51 nCPM
megakaryocyte-erythroid progenitors: 42 nCPM

Immune cell

memory B-cell: 8.5 nTPM
NK-cell: 7.7 nTPM
naive B-cell: 7.1 nTPM
T-reg: 5 nTPM
basophil: 4.7 nTPM
MAIT T-cell: 4.4 nTPM

Brain region

cerebellum: 13 nTPM
white matter: 11 nTPM
spinal cord: 9.4 nTPM
cerebral cortex: 8.6 nTPM
medulla oblongata: 8.4 nTPM
pons: 8.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.84
gnomAD pLI: 0
gnomAD missense Z: 0.29
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF92 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF92 as an antibody target. Whether an autoantibody or antibody against ZNF92 could matter depends on whether native ZNF92 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF92 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF92 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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