Seroatlas · Human Serome Atlas

ZNF91

Zinc finger protein 91

Also known as: HPF7, HTF10, ZNF91_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q05481
Gene: ZNF91
Ensembl: ENSG00000167232
Chromosome: 19
Canonical length: 1191 aa
Protein class: Cancer-related genes, Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

The ZNF91 gene encodes a zinc finger protein of the KRAB (Kruppel-associated box) subfamily (Bellefroid et al., 1991, 1993 [PubMed 2023909] [PubMed 8467795]).[supplied by OMIM, May 2010]

Canonical amino-acid sequenceUniProt

1191 residues, UniProt reviewed canonical sequence.

>Q05481|ZNF91
     1  MPGTPGSLEM GLLTFRDVAI EFSPEEWQCL DTAQQNLYRN VMLENYRNLA FLGIALSKPD
    61  LITYLEQGKE PWNMKQHEMV DEPTGICPHF PQDFWPEQSM EDSFQKVLLR KYEKCGHENL
   121  QLRKGCKSVD ECKVHKEGYN KLNQCLTTAQ SKVFQCGKYL KVFYKFLNSN RHTIRHTGKK
   181  CFKCKKCVKS FCIRLHKTQH KCVYITEKSC KCKECEKTFH WSSTLTNHKE IHTEDKPYKC
   241  EECGKAFKQL STLTTHKIIC AKEKIYKCEE CGKAFLWSST LTRHKRIHTG EKPYKCEECG
   301  KAFSHSSTLA KHKRIHTGEK PYKCEECGKA FSRSSTLAKH KRIHTGEKPY KCKECGKAFS
   361  NSSTLANHKI THTEEKPYKC KECDKAFKRL STLTKHKIIH AGEKLYKCEE CGKAFNRSSN
   421  LTIHKFIHTG EKPYKCEECG KAFNWSSSLT KHKRFHTREK PFKCKECGKA FIWSSTLTRH
   481  KRIHTGEKPY KCEECGKAFR QSSTLTKHKI IHTGEKPYKF EECGKAFRQS LTLNKHKIIH
   541  SREKPYKCKE CGKAFKQFST LTTHKIIHAG KKLYKCEECG KAFNHSSSLS THKIIHTGEK
   601  SYKCEECGKA FLWSSTLRRH KRIHTGEKPY KCEECGKAFS HSSALAKHKR IHTGEKPYKC
   661  KECGKAFSNS STLANHKITH TEEKPYKCKE CDKTFKRLST LTKHKIIHAG EKLYKCEECG
   721  KAFNRSSNLT IHKFIHTGEK PYKCEECGKA FNWSSSLTKH KRIHTREKPF KCKECGKAFI
   781  WSSTLTRHKR IHTGEKPYKC EECGKAFSRS STLTKHKTIH TGEKPYKCKE CGKAFKHSSA
   841  LAKHKIIHAG EKLYKCEECG KAFNQSSNLT THKIIHTKEK PSKSEECDKA FIWSSTLTEH
   901  KRIHTREKTY KCEECGKAFS QPSHLTTHKR MHTGEKPYKC EECGKAFSQS STLTTHKIIH
   961  TGEKPYKCEE CGKAFRKSST LTEHKIIHTG EKPYKCEECG KAFSQSSTLT RHTRMHTGEK
  1021  PYKCEECGKA FNRSSKLTTH KIIHTGEKPY KCEECGKAFI SSSTLNGHKR IHTREKPYKC
  1081  EECGKAFSQS STLTRHKRLH TGEKPYKCGE CGKAFKESSA LTKHKIIHTG EKPYKCEKCG
  1141  KAFNQSSILT NHKKIHTITP VIPLLWEAEA GGSRGQEMET ILANTVKPLL Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF91 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

retina: 13 nTPM
small intestine: 13 nTPM
duodenum: 12 nTPM
rectum: 9.9 nTPM
thyroid gland: 9.8 nTPM
colon: 9.6 nTPM

Single-cell type

late spermatids: 678 nCPM
early spermatids: 427 nCPM
cardiomyocytes: 350 nCPM
myonuclei: 319 nCPM
syncytiotrophoblasts: 250 nCPM
prostatic glandular cells: 235 nCPM

Immune cell

naive CD4 T-cell: 10 nTPM
naive CD8 T-cell: 8.1 nTPM
memory CD4 T-cell: 7.2 nTPM
naive B-cell: 7.1 nTPM
memory CD8 T-cell: 6.5 nTPM
gdT-cell: 6 nTPM

Brain region

cerebellum: 142 nTPM
basal ganglia: 100 nTPM
cerebral cortex: 99 nTPM
hippocampal formation: 95 nTPM
white matter: 94 nTPM
pons: 87 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0.44
gnomAD missense Z: -0.55
DepMap mean gene effect: -0.28
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF91 as an antibody target. Whether an autoantibody or antibody against ZNF91 could matter depends on whether native ZNF91 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF91 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF91 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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