Seroatlas · Human Serome Atlas

ZNF90

Zinc finger protein 90

Also known as: HTF9, ZNF90_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q03938
Gene: ZNF90
Ensembl: ENSG00000213988
Chromosome: 19
Canonical length: 601 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

601 residues, UniProt reviewed canonical sequence.

>Q03938|ZNF90
     1  MGPLEFRDVA IEFSLEEWHC LDTAQQNLYR DVMLENYRHL VFLGIVVTKP DLITCLEQGK
    61  KPFTVKRHEM IAKSPVMCFH FAQDLCPEQS LKDSFQKVIV TRYEKREYGN LELKKGCESV
   121  DEGKVHKRGY NGLNQCLTAT QSKVFQCDTY VKVSHIFSNS NRHKIRDTGK KPFKCIECGK
   181  AFNQSSTLAT HKKIHTGEIT CKCEECGKAF NRSSHLTSHK RIHTGEKRYK CEDCGKELKY
   241  SSTLTAHKRI HTGEKRYKCE DCGKELKYSS TLTAHKRIHT GEKPYKCDKC GRAFISSSIL
   301  YVHKISHTEE KPYKCEECGK AFKLSSILST HKRIHTGEKP YKCEECGKAF RRSLVLRTHK
   361  RIHTGEKPYK CDKCGKAFIS SSLLYKHKIS HSEKKPYKCE ECGKAFKRSS TLTIHKISHT
   421  EEKPYKCQEC DKVFKRSSAL STHKIIHSGE KPYKCEECGK AFKRSSNLTT HKISHTEEKL
   481  YKCQECDKAF KYSSALSTHK IIHSGENPYK CEECGKAFKR SSVLSKHKII HTGAKPYKCE
   541  ECGKAFKRSS QLTSHKISHT GEKPYKCEEC GKAFNLSSDL NTHKRIHIGQ KAYIVKNMAN
   601  L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF90 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 2 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 2 nTPM
parathyroid gland: 1.7 nTPM
ovary: 1.3 nTPM
seminal vesicle: 1.3 nTPM
placenta: 1.2 nTPM
lymph node: 1.1 nTPM

Single-cell type

papillary tip epithelial cells: 76 nCPM
loop of henle epithelial cells: 40 nCPM
renal collecting duct principal cells: 39 nCPM
pituicytes/fscs: 34 nCPM
renal connecting tubule cells: 30 nCPM
prostatic hillock cells: 26 nCPM

Immune cell

neutrophil: 0.2 nTPM
MAIT T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 2.5 nTPM
white matter: 1.3 nTPM
basal ganglia: 1.2 nTPM
thalamus: 1.2 nTPM
medulla oblongata: 1.1 nTPM
midbrain: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.69
gnomAD pLI: 0
gnomAD missense Z: -1.04
DepMap mean gene effect: 0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF90 as an antibody target. Whether an autoantibody or antibody against ZNF90 could matter depends on whether native ZNF90 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF90 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF90 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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