ZNF891
Zinc finger protein 891
Also known as: ZN891_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A8MT65
- Gene
- ZNF891
- Ensembl
- ENSG00000214029
- Chromosome
- 12
- Canonical length
- 544 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm,Vesicles
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
544 residues, UniProt reviewed canonical sequence.
>A8MT65|ZNF891
1 MAVMDLSSPW ALTKQDSACF HLRNAEEERM IAVFLTTWLQ EPMTFKDVAV EFTQEEWMML
61 DSAQRSLYRD VMLENYRNLT SVEYQLYRLT VISPLDQEEI RNMKKRIPQA ICPDQKIQPK
121 TKESTVQKIL WEEPSNAVKM IKLTMHNWSS TLREDWECHK IRKQHKIPGG HWRQMIYAPK
181 KTVPQELFRD YHELEENSKL GSKLIFSQSI FTSKHCQKCY SEIGCLKHNS IINNYVKNSI
241 SEKLYESHEC DTTLWHFQRN QTVQKEYTYS KHGMHFTHNM FPVPNNLHMA QNACECNKDE
301 TLCHQSSLKK QGQTHTEKKH ECNQCGKAFK RISNLTLYKK SHMGEKQYEC KECGKVFNDS
361 STLRRHVRTH TGEKPYECNQ CGKAFSQKTS LKAHMRTHTG EKPYECNQCG KSFGTSSYLI
421 VHKRIHTGEK LYECSECGKA FNTSSHLKVH KKIHTGENVY ECSDCGKVFS GVSSLRMHIR
481 THTGEKPYEC KECRKAFSVS SSLRRHVRIH TGEKPYECIQ CGKAFSQSSS LIIHKRIHTE
541 RETLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF891 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.53
- Highest tissue expression
- 4.4 nTPM
Expression across tissuesHPA
Tissue
- retina: 4.4 nTPM
- testis: 4.4 nTPM
- ovary: 2.3 nTPM
- blood vessel: 2 nTPM
- endometrium: 2 nTPM
- cerebellum: 1.9 nTPM
Single-cell type
- epicardial cells: 73 nCPM
- early spermatids: 69 nCPM
- lactotrophs: 62 nCPM
- thyrotrophs: 56 nCPM
- late primary spermatocytes: 55 nCPM
- cardiomyocytes: 49 nCPM
Immune cell
- naive B-cell: 1.3 nTPM
- naive CD4 T-cell: 1.3 nTPM
- naive CD8 T-cell: 1.3 nTPM
- memory B-cell: 1.1 nTPM
- gdT-cell: 0.9 nTPM
- memory CD8 T-cell: 0.9 nTPM
Brain region
- cerebellum: 13 nTPM
- white matter: 11 nTPM
- basal ganglia: 8.9 nTPM
- cerebral cortex: 8.7 nTPM
- hippocampal formation: 8.6 nTPM
- hypothalamus: 8.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.13
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.25
- DepMap mean gene effect
- 0.01
- DepMap dependency class
- none
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II transcription regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF891 as an antibody target. Whether an autoantibody or antibody against ZNF891 could matter depends on whether native ZNF891 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF891 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF891 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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