ZNF888
Zinc finger protein 888
Also known as: ZN888_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P0CJ79
- Gene
- ZNF888
- Ensembl
- ENSG00000213793
- Chromosome
- 19
- Canonical length
- 718 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
718 residues, UniProt reviewed canonical sequence.
>P0CJ79|ZNF888
1 MALPQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS SKCMMEFSSI
61 GKGNTEVIHT GTLQRLASHH IGECCFQEIE KDIHDFVFQW QEDETNGHEA PMTEIKELTG
121 STDQYDQRHA GNKPIKYQLG SSFHSHLPEL HIFQPEGKIG NQLEKSINNA SSVSTSQRIS
181 CRPKTHISNN YGNNFFHSSL LTQKQDVHRK EKSFQFNESG KSFNCSSLFK KHQIIHLGEK
241 QYKCDVCGKD FNQKRYLAHH RRCHTGEKPY MCNKCGKVFN KKAYLARHYR RHTGEKPYKC
301 NECGKTFSDK SALLVHKTIH TGEKPYKCNE CGKVFNQQSN LARHHRVHTG EKPYQCKECD
361 KVFSRKSYLE RHRRIHTGEK PYKCKVCDKA FRHDSHLAQH IVIHTREKPY KCNECGKTFG
421 ENSALLVHKT IHTGEKPYKC NECGKVFNQQ SNLARHHRLH TGEKPYKCKE CDKVFSRKSH
481 LERHRRIHTG EKPYKCKVCD KAFRRDSHLA QHTVIHTGEK PYKCNECGKT FVQNSSLVMH
541 KVIHTGEKRY KCNECGKSFN HKSSLAYHHR LHTGEKPYKC NECGKVFRTQ SQLACHHRLH
601 TGEKPYKCEE CDKVFNIKSH LEIHRRVHTG EKPYKCRVCD KAFGRDSYLA QHQRVHTGEK
661 PYKCKVCDKA FKCYSHLAQH TRIHTGEKPF KCSECGKAFR AQSTLIHHQA IHGVGKLDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF888 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.47
- Highest tissue expression
- 12 nTPM
Expression across tissuesHPA
Tissue
- cervix: 12 nTPM
- urinary bladder: 10 nTPM
- prostate: 8.6 nTPM
- fallopian tube: 8 nTPM
- rectum: 7.7 nTPM
- stomach: 7.2 nTPM
Single-cell type
- endometrial glandular cells: 50 nCPM
- endometrial ciliated cells: 47 nCPM
- prostatic hillock cells: 45 nCPM
- urothelial cells: 38 nCPM
- endometrial luminal cells: 32 nCPM
- basal prostatic cells: 29 nCPM
Immune cell
- plasmacytoid DC: 2.3 nTPM
- NK-cell: 1.2 nTPM
- eosinophil: 1 nTPM
- myeloid DC: 1 nTPM
- T-reg: 0.9 nTPM
- classical monocyte: 0.8 nTPM
Brain region
- cerebellum: 4.6 nTPM
- choroid plexus: 4 nTPM
- cerebral cortex: 3.2 nTPM
- amygdala: 3 nTPM
- hypothalamus: 3 nTPM
- pons: 2.9 nTPM
OntologyGO
Biological processes
- regulation of transcription by RNA polymerase II
- regulation of anatomical structure morphogenesis
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF888 as an antibody target. Whether an autoantibody or antibody against ZNF888 could matter depends on whether native ZNF888 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF888 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF888 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...