ZNF883
Zinc finger protein 883
Also known as: ZN883_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P0CG24
- Gene
- ZNF883
- Ensembl
- ENSG00000228623
- Chromosome
- 9
- Canonical length
- 379 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
OverviewNCBI Gene
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
379 residues, UniProt reviewed canonical sequence.
>P0CG24|ZNF883
1 MESEKIYMTA NPYLCTECGK GYTCLASLTQ HQKTHIGEKP YECKICGKSF TRNSNLVQHQ
61 RIHTGEKPYE CNECGKAFSQ STNLIQHQRV HTGEKPYECN ECEKTFSHRS SLRNHERIHT
121 GEKPYPCNEC GKAFSHISAL TQHHRIHTGK KPYECTECGK TFSRSTHLIE HQGIHSEEKS
181 YQCKQCRKVF CHSTSLIRHQ RTHTGEKPYE CNECGKAFSH TPAFIQHQRI HTGEKPYECN
241 ACGKAFNRSA HLTEHQRTHT GEKPYVCKEC GKTFSRSTHL TEHLKIHSCV KPYQCNECQK
301 LFCYRTSLIR HQRTHTGEKP YQCNECGKSF SLSSALTKHK RIHTRERPYQ CTKCGDVFCH
361 STSLIRHQKT HFRKETLAELocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZNF883 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.39
- Highest tissue expression
- 7.7 nTPM
Expression across tissuesHPA
Tissue
- retina: 7.7 nTPM
- bone marrow: 2.9 nTPM
- cerebral cortex: 2.2 nTPM
- testis: 2.2 nTPM
- skin: 1.8 nTPM
- epididymis: 1.3 nTPM
Single-cell type
- brain inhibitory neurons: 68 nCPM
- oligodendrocyte progenitor cells: 59 nCPM
- astrocytes: 42 nCPM
- brain excitatory neurons: 34 nCPM
- oligodendrocytes: 33 nCPM
- other brain neurons: 18 nCPM
Immune cell
- basophil: 0.8 nTPM
- neutrophil: 0.5 nTPM
- naive B-cell: 0.4 nTPM
- naive CD8 T-cell: 0.4 nTPM
- gdT-cell: 0.3 nTPM
- MAIT T-cell: 0.3 nTPM
Brain region
- cerebral cortex: 48 nTPM
- cerebellum: 47 nTPM
- white matter: 47 nTPM
- thalamus: 42 nTPM
- amygdala: 41 nTPM
- basal ganglia: 40 nTPM
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
- DNA-binding transcription factor activity, RNA polymerase II-specific
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZNF883 as an antibody target. Whether an autoantibody or antibody against ZNF883 could matter depends on whether native ZNF883 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZNF883 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZNF883 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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