Seroatlas · Human Serome Atlas

ZNF880

Zinc finger protein 880

Also known as: ZN880_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6PDB4
Gene: ZNF880
Ensembl: ENSG00000221923
Chromosome: 19
Canonical length: 577 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Intermediate filaments

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

577 residues, UniProt reviewed canonical sequence.

>Q6PDB4|ZNF880
     1  MLRRGHLAFR DVAIEFPQEE WKCLDPAQRT LYREVMVENY RNLVFLGICL PDLSVISMLE
    61  QRRDPRNLQS EVKIANNPGG RECIKGVNAE SSSKLGSNAG NKSLKNQLGL TFQLHLSELQ
   121  LFQAERNISG CKHVEKPINN SLVSPLQKIY SSVKSHILNK YRNDFDDSPF LPQEQKAQIR
   181  EKPCECNEHG KAFRVSSRLA NNQVIHTADN PYKCNECDKV FSNSSNLVQH QRIHTGEKPY
   241  KCHECGKLFN RISLLARHQR IHTGEKPYKC HECGKVFTQN SHLANHHRIH TGEKPYKCNE
   301  CGKVFNRNAH LARHQKIHSG EKPYKCKECG KAFSGGSGLT AHLVIHTGEK LYKCNKCGKV
   361  FNRNAHLTRH QRIHTGEKPY ECKECGKVFR HKFCLTNHHR MHTGEQPYKC NECGKAFRDC
   421  SGLTAHLLIH TGEKPYKCKE CAKVFRHRLS LSNHQRFHTG EKPYRCDECG KDFTRNSNLA
   481  NHHRIHTGEK PYKCSECHKV FSHNSHLARH RQIHTGEKSY KCNECGKVFS HKLYLKKHER
   541  IHTGEKPYRC HECGKDFTRN SNLANHHRIH TGEKPYR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF880 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 17 nTPM
bone marrow: 16 nTPM
heart muscle: 16 nTPM
ovary: 16 nTPM
prostate: 16 nTPM
retina: 15 nTPM

Single-cell type

epididymal principal cells: 36 nCPM
extravillous trophoblasts: 30 nCPM
syncytiotrophoblasts: 23 nCPM
migrating cytotrophoblasts: 22 nCPM
prostatic glandular cells: 19 nCPM
retinal horizontal cells: 18 nCPM

Immune cell

basophil: 80 nTPM
naive B-cell: 54 nTPM
memory B-cell: 51 nTPM
plasmacytoid DC: 41 nTPM
naive CD4 T-cell: 38 nTPM
T-reg: 37 nTPM

Brain region

cerebellum: 65 nTPM
white matter: 42 nTPM
pons: 41 nTPM
thalamus: 41 nTPM
midbrain: 40 nTPM
medulla oblongata: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.69
gnomAD pLI: 0
gnomAD missense Z: 0.24
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF880 as an antibody target. Whether an autoantibody or antibody against ZNF880 could matter depends on whether native ZNF880 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF880 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF880 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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