Seroatlas · Human Serome Atlas

ZNF879

Zinc finger protein 879

Also known as: DKFZp686E2433, ZN879_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: B4DU55
Gene: ZNF879
Ensembl: ENSG00000234284
Chromosome: 5
Canonical length: 563 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a kruppel-associated box-containing zinc finger protein (KRAB-ZFP). The encoded protein contains an N-terminal kruppel-associated box (KRAB) domain and thirteen C-terminal C2H2-type zinc finger domains. The KRAB-ZFPs represent the largest family of mammalian transcriptional repressors, which function through the recruitment of the nuclear co-factor KRAB-Associated Protein 1 (KAP1), to engage histone modifiers and induce heterochromatin formation. [provided by RefSeq, Jul 2017]

Canonical amino-acid sequenceUniProt

563 residues, UniProt reviewed canonical sequence.

>B4DU55|ZNF879
     1  MARRLLPAHV QESVTFRDVA VFFSQDEWLH LDSAQRALYR EVMLENYSIL VSLGILFSKP
    61  KVISQLEQGE DPWMVESGVP QGAHLGWESL FGTIVSKEEN QEVMKKLIID GTFDFKLEKT
   121  YINEDKLEKQ QGKKNRLFSK VLVTIKKVYM KERSFKGVEF GKNLGLKSSL IRKPRIVSRG
   181  RRPRSQQYSV LFKQLGVNTV RKCYKCNICG KIFLHSSSLS KHQRIHTGEK LYKCKECRKA
   241  FSQSSSLTQH LRVHTGEKPY ICSECGKAFS FTTSLIGHQR MHTGERPYKC KECGKTFKGS
   301  SSLNNHQRIH TGEKPYKCNE CGRAFSQCSS LIQHHRIHTG EKPYECTQCG KAFTSISRLS
   361  RHHRIHTGEK PFHCNECGKV FSYHSALIIH QRIHTGEKPY ACKECGKAFS QSSALIQHQR
   421  IHTGEKPYKC NECGKAFSWI SRLNIHHRIH TGEKPYNCKE CGKAFSSHSG VNTHRKIHTG
   481  EKPYKCNDCE KAFNQSSALI QHQRIHTGEK PYNCKVCGKA FRQSSSLMTH MRIHTGEKPY
   541  KCKECGKAFS QSSSLTNHQR THN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF879 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 6.6 nTPM

Expression across tissuesHPA

Tissue

retina: 6.6 nTPM
testis: 5.8 nTPM
cerebellum: 4.4 nTPM
thyroid gland: 3.5 nTPM
skin: 3.3 nTPM
tonsil: 3.3 nTPM

Single-cell type

differentiating spermatogonia: 14 nCPM
oocytes: 14 nCPM
late primary spermatocytes: 13 nCPM
early primary spermatocytes: 12 nCPM
undifferentiated spermatogonia: 8.1 nCPM
retinal horizontal cells: 8 nCPM

Immune cell

basophil: 14 nTPM
naive CD4 T-cell: 6.7 nTPM
T-reg: 6 nTPM
NK-cell: 5.4 nTPM
naive CD8 T-cell: 5.2 nTPM
gdT-cell: 4.9 nTPM

Brain region

white matter: 9.8 nTPM
cerebellum: 8.8 nTPM
basal ganglia: 8.3 nTPM
medulla oblongata: 8 nTPM
midbrain: 7.4 nTPM
cerebral cortex: 7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 1.61
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF879 as an antibody target. Whether an autoantibody or antibody against ZNF879 could matter depends on whether native ZNF879 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF879 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF879 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...